Department of Medicine, Division of Infectious Disease, Baylor College of Medicine, United States.
J Infect. 2011 Nov;63(5):394-7. doi: 10.1016/j.jinf.2011.08.002. Epub 2011 Aug 9.
Infectious diarrhea is a common occurrence in the immunosuppressed population. We present a 43-year-old individual with large-volume stool output Norovirus acute gastroenteritis in the setting of relapsed refractory acute myelogenous leukemia, hematopoietic stem cell transplantation, and biopsy-proven cutaneous and pulmonary graft-versus-host disease. Therapeutic options such as intravenous immunoglobulin or reduction of immunosuppressants were not a feasible choice. A prompt clinical cure was achieved with nitazoxanide, a broad-spectrum antimicrobial agent. Nitazoxanide may be a safe therapeutic alternative, in which a reduction in immunosuppression may not be a viable option.
感染性腹泻在免疫抑制人群中很常见。我们报告了 1 例 43 岁个体，在复发性难治性急性髓性白血病、造血干细胞移植和经活检证实的皮肤和肺移植物抗宿主病背景下，出现大量粪便排出诺如病毒急性胃肠炎。静脉注射免疫球蛋白或减少免疫抑制剂等治疗选择并不可行。使用硝唑尼特（一种广谱抗菌药物）迅速获得临床治愈。硝唑尼特可能是一种安全的治疗选择，在这种情况下，减少免疫抑制可能不是可行的选择。
