National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control & Prevention, Atlanta, GA, USA.
Psychiatry Res. 2011 Sep 30;189(2):318-20. doi: 10.1016/j.psychres.2011.07.015. Epub 2011 Aug 15.
We studied the impact of cumulative life stress on CFS in a population-based study. We found that exposure to stressors was significantly more common in persons with CFS compared to NF controls; those with CFS reported experiencing significantly higher levels of psychological distress. Also, post-traumatic stress disorder was significantly more common in people with CFS. These results not only corroborate findings from other studies but, importantly, extend those by: a) measuring a comprehensive spectrum of stress variables, b) for the first time presenting data on stress in a population-based study, thus minimizing the effects of recruitment bias, and c) diagnosing CFS by means of standardized, validated scales, thus allowing replication and extension of our findings. Stress may be an important factor in the pathophysiology of CFS. Consequently, future studies should provide a more detailed understanding of the processes that lead from stress to CFS using longitudinal designs.
我们在一项基于人群的研究中研究了累积生活压力对 CFS 的影响。我们发现，与 NF 对照组相比，CFS 患者暴露于压力源的情况更为常见；CFS 患者报告经历了更高水平的心理困扰。此外，创伤后应激障碍在 CFS 患者中也更为常见。这些结果不仅证实了其他研究的发现，而且重要的是，通过以下方式扩展了这些发现：a）测量了一系列全面的压力变量，b）首次在基于人群的研究中呈现了压力数据，从而最小化了招募偏差的影响，c）通过标准化、经过验证的量表来诊断 CFS，从而允许对我们的发现进行复制和扩展。压力可能是 CFS 病理生理学中的一个重要因素。因此，未来的研究应该使用纵向设计，更详细地了解从压力到 CFS 的发展过程。
