一例慢性粒单核细胞白血病患者，在白细胞增多稳定控制期间出现心包积液。

A case of chronic myelomonocytic leukemia who developed pericardial effusion during stably controlled leukocytosis.

作者信息

Morita Yasuyoshi, Ohyama Yuichi, Rai Shinya, Kawauchi Masaya, Yamaguchi Terufumi, Shimada Takahiro, Tatsumi Yoichi, Ashida Takashi, Maeda Yasuhiro, Matsumura Itaru

机构信息

Department of Hematology, Kinki University School of Medicine, Japan.

出版信息

Intern Med. 2011;50(16):1737-40. doi: 10.2169/internalmedicine.50.5287. Epub 2011 Aug 15.

DOI:10.2169/internalmedicine.50.5287

PMID:21841336

Abstract

We report a rare case of chronic myelomonocytic leukemia (CMML) with pericardial effusion. After receving the diagnosis of CMML, she had been successfully treated with hydroxycarbamide (HU). However, she was admitted to our hospital due to pericardial effusion. The majority of the cells in the pericardial fluid were monocytes. We made the diagnosis of pericardial involvement with CMML cells and intravenously administered etoposide (100 mg/body daily for 5 days). Although CMML cells disappeared from the peripheral blood, the pericardial effusion still persisted. This case indicates that pericardial effusion is a possible and life-threatening complication in CMML patients despite stably controlled leukocytes.

摘要

我们报告一例罕见的慢性粒单核细胞白血病（CMML）合并心包积液的病例。在被诊断为CMML后，她曾成功接受羟基脲（HU）治疗。然而，她因心包积液入住我院。心包积液中的大多数细胞为单核细胞。我们诊断为心包受CMML细胞累及，并静脉给予依托泊苷（每日100mg/体，共5天）。尽管外周血中的CMML细胞消失，但心包积液仍然存在。该病例表明，尽管白细胞得到稳定控制，但心包积液仍是CMML患者可能出现的危及生命的并发症。