Faure G C, Béné M C, Simon C, Quantain A
Laboratoire d'Immunologie, UFR Sciences Médicales de Nancy, Vandoeuvre, France.
Int J Immunopharmacol. 1990;12(3):315-20. doi: 10.1016/0192-0561(90)90087-4.
Thirty subjects who had received an oral ribosomal vaccine to common bacteria of upper respiratory tract infections, and ten controls were tonsillectomized for recurrent infections or rhonchologic pathology. A three-step indirect immunofluorescence technique was used to identify and enumerate specific antibody forming cells (SAFC) in their tonsils. Plasma-cells specific of the four strains being constituents of the oral vaccine (H. influenzae, K. pneumoniae, S. pyogenes and S. pneumoniae) were observed in all samples. The numbers of SAFC were significantly higher in the subjects who had received the oral vaccine. These results support the efficiency or oral immunization in increasing local defenses, even at distance from the sensitized gut-associated lymphoid tissue. These data provide evidence for the homing phenomenon in human mucosae associated lymphoid tissue (MALT).
30名曾接受针对上呼吸道感染常见细菌的口服核糖体疫苗的受试者，以及10名因反复感染或呼吸道疾病而接受扁桃体切除术的对照者。采用三步间接免疫荧光技术来识别和计数他们扁桃体中的特异性抗体形成细胞（SAFC）。在所有样本中均观察到了针对口服疫苗的四种菌株（流感嗜血杆菌、肺炎克雷伯菌、化脓性链球菌和肺炎链球菌）的特异性浆细胞。接受口服疫苗的受试者中的SAFC数量显著更高。这些结果支持了口服免疫在增强局部防御方面的有效性，即使远离致敏的肠道相关淋巴组织。这些数据为人类黏膜相关淋巴组织（MALT）中的归巢现象提供了证据。
