Meng Xian-Jie, Wan Yi-Gang, Wei Qing-Xue, Chen Hao-Li, Shi Xi-Miao, Huang Yan-Ru, Yao Jian
Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China.
Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
Zhongguo Zhong Yao Za Zhi. 2013 Nov;38(21):3651-5.
The effective bioactivity compositions of uremic clearance granul (UCG) include isoflavonoids, emodin, astragaloside, paeoniflorin, salvianolic acid A, and so on. The effects of UCG treating chronic renal failure (CRF) in clinical pharmacodynamics mainly refer to improve renal function and the complications of CRF. The mechanisms involved in vivo basically include depressing transforming growth factor (TGF)-beta1 over-expression, lessening podocyte injury,inhibiting tubular epithelial myofibroblast transdifferentiation, ameliorating microinflammation status, retarding oxidative stress, and alleviating insulin resistance.
尿毒清颗粒（UCG）的有效生物活性成分包括异黄酮类、大黄素、黄芪甲苷、芍药苷、丹酚酸A等。UCG治疗慢性肾衰竭（CRF）的临床药效学作用主要指改善肾功能及CRF的并发症。其体内作用机制主要包括抑制转化生长因子（TGF）-β1过度表达、减轻足细胞损伤、抑制肾小管上皮肌成纤维细胞转分化、改善微炎症状态、延缓氧化应激及减轻胰岛素抵抗。
