Lv Ziming, Zhang Qingjian, Chen Ruoyun, Yu Dequan
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhongguo Zhong Yao Za Zhi. 2011 May;36(9):1190-2.
To investigate the chemical constituents of the branches and leaves of Uvaria kurzii.
The compounds were isolated and purified by silica gel and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.
Nine compounds were isolated and identified as: bidebiline A(1), annobraine (2), oxoputerine (3), atherospermidine (4), liriodenine (5), physcion (6), questin (7), rubiadin 3-methyl ether (8), emodin (9).
Compound 1-4, 6-9 were isolated from the genus Uvaria for the first time. Compound 3-5 showed inhabitation activities against tumor cell lines A549, Bel7402, BGC823, HCT-8, A2780, respectively.
研究毛叶紫玉盘枝叶的化学成分。
采用硅胶柱色谱和葡聚糖凝胶LH - 20柱色谱法对化合物进行分离纯化，并根据其理化性质和光谱数据确定化学结构。
分离鉴定出9个化合物，分别为：双去甲氧基紫玉盘碱A（1）、阿诺布灵（2）、氧代乌药碱（3）、南美番荔枝碱（4）、鹅掌楸碱（5）、大黄素甲醚（6）、奎斯亭（7）、茜草素 - 3 - 甲醚（8）、大黄素（9）。
化合物1 - 4、6 - 9为首次从紫玉盘属植物中分离得到。化合物3 - 5分别对肿瘤细胞株A549、Bel7402、BGC823、HCT - 8、A2780显示出抑制活性。
