Xu Qiong-ming, Liu Yan-li, Zhao Bao-hua, Xu Li-zhen, Yang Shi-lin, Chen Shao-hua
College of Pharmacy, Soochow University, Suzhou 215123, China.
Yao Xue Xue Bao. 2007 Apr;42(4):405-7.
Uvaria kweichowensis is a folk nongovernmental herb used to treat cure inflammation and tumour in the Southwest area of China. During the course of our investigation for antitumour agents from the stems of Uvaria kweichowensis, six amides were obtained by means of solvent extraction, chromatography on silica gel and Sephadex LH-20 repeatedly. And their structures were identified as uvariadiamide (1), cepharanone (2), aristololactam A II (3), enterocarpam II (4), aristololactam A Ia (5), and 4,5-dioxodehydroasimilobine (6) on the basis of chemical methods and spectral analyses (EI-MS, 1H NMR, 13C NMR). Among them, compound 1 is a new compound; the other compounds were obtained from this plant for the first time.
贵州紫玉盘是中国西南地区用于治疗炎症和肿瘤的一种民间草药。在我们从贵州紫玉盘茎中寻找抗肿瘤药物的研究过程中，通过溶剂萃取、硅胶柱色谱和反复使用葡聚糖凝胶LH - 20，得到了六种酰胺类化合物。并通过化学方法和光谱分析（EI-MS、¹H NMR、¹³C NMR）确定它们的结构分别为紫玉盘二酰胺（1）、千金藤酮（2）、马兜铃内酰胺A II（3）、内盘酰胺II（4）、马兜铃内酰胺A Ia（5）和4,5-二氧脱氢阿西米洛宾（6）。其中，化合物1是新化合物；其他化合物均首次从该植物中获得。
