[山核桃的化学成分及其抗肿瘤生物活性]
[Chemical constituents of Carya cathayensis and their antitumor bioactivity].
作者信息
Wu De-lin, Chen Shi-yun, Liu Jing-song, Jin Chuan-shan, Xu Feng-qing
机构信息
College of Pharmaceutical Sciences of Anhui University of Traditional Chinese Medicine, Hefei 230031, China.
出版信息
Zhong Yao Cai. 2011 Jul;34(7):1055-7.
OBJECTIVE
To investigate the chemical constituents of Carya cathayensis and their antitumor bioactivity.
METHODS
The compounds were isolated by Sephadex LH-20 and silica gel column chromatography. Their structures were identified by physicochemical properties and spectroscopic analysis. Then their cytotoxic activity was studied.
RESULTS
Five compounds were elucidated as chrysophanol (1), physcion (2), beta-sitosterol (3), pinostrobin(4), 4,8-dihydroxy-1-tetralone (5).
CONCLUSION
Compounds 2 and 5 are isolated from Carya cathayensis for the first time. In the MTT antitumor experiments, the compounds 1,4 and 5 have the cytotoxic activity to KB cell.
目的
研究山核桃的化学成分及其抗肿瘤生物活性。
方法
通过葡聚糖凝胶LH - 20和硅胶柱色谱法分离化合物。通过理化性质和光谱分析鉴定其结构。然后研究它们的细胞毒性活性。
结果
鉴定出5种化合物，分别为大黄酚（1）、大黄素甲醚（2）、β-谷甾醇（3）、豆甾酮（4）、4,8 - 二羟基-1 - 四氢萘酮（5）。
结论
化合物2和5首次从山核桃中分离得到。在MTT抗肿瘤实验中，化合物1、4和5对KB细胞具有细胞毒性活性。
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