N-烟酰基多巴胺，一种新型烟酰胺衍生物，保留了高抗氧化活性，并抑制皮肤色素沉着。

N-Nicotinoyl dopamine, a novel niacinamide derivative, retains high antioxidant activity and inhibits skin pigmentation.

机构信息

Enprani Co., Ltd., R&D Center of Skin Science and Cosmetics, Incheon, Korea.

出版信息

Exp Dermatol. 2011 Nov;20(11):950-2. doi: 10.1111/j.1600-0625.2011.01345.x. Epub 2011 Aug 15.

DOI:10.1111/j.1600-0625.2011.01345.x

Abstract

We synthesized a novel derivative of a well-known skin-lightening compound niacinamide, N-nicotinoyl dopamine (NND). NND did not show inhibitory effects of tyrosinase and melanin synthesis in B16F10 mouse melanoma cells. However, NND retains high antioxidant activity without affecting viability of cells. In a reconstructed skin model, topical applications of 0.05% and 0.1% NND induced skin lightening and decreased melanin production without affecting the viability and morphology of melanocytes and overall tissue histology. Moreover, no evidence for skin irritation or sensitization was observed when 0.1% NND emulsion was applied onto the skin of 52 volunteers. The effect of NND on skin lightening was further revealed by pigmented spot analyses of human clinical trial. Overall, NND treatment may be a useful trial for skin lightening and treating pigmentary disorders.

摘要

我们合成了一种众所周知的皮肤美白化合物烟酰胺的新型衍生物，即 N-烟酰基多巴胺（NND）。NND 对 B16F10 小鼠黑色素瘤细胞中的酪氨酸酶和黑色素合成没有抑制作用。然而，NND 保留了高抗氧化活性，而不影响细胞活力。在重建的皮肤模型中，0.05%和 0.1%的 NND 局部应用可使皮肤变白并减少黑色素生成，而不影响黑素细胞的活力和形态以及整体组织组织学。此外，当将 0.1%的 NND 乳剂涂抹在 52 名志愿者的皮肤上时，没有观察到皮肤刺激或致敏的证据。NND 对皮肤美白的作用通过人体临床试验的色素斑分析进一步揭示。总的来说，NND 治疗可能是皮肤美白和治疗色素沉着障碍的一种有用方法。