用于根除表皮葡萄球菌的烟酰胺棒剂的制备及药学评价
Preparation and pharmaceutical evaluation of nicotinamide stick for eradication of Staphylococcus epidermidis.
作者信息
Shahtalebi Mohammad Ali, Bahrinajafi Rahim, Nahavandi Sima
机构信息
Department of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Res Med Sci. 2014 Jul;19(7):654-7.
BACKGROUND
Staphylococcus epidermidis is a part of the skin's normal flora that can cause acne. This study was designed to evaluate the efficacy of nicotinamide as a stick in eradication of staphylococcus.
MATERIALS AND METHODS
For evaluating of Anti-microbial effect on S. epidermidis used well plate method. We chose five plates for nicotinamide and five for mupirocin. The zones of inhibition were measured and compared.
RESULTS
The results showed nicotinamide stick had anti-microbial effects, but in comparison to mupirocin it was significantly less (P = 0.003).
CONCLUSION
Nicotinamide stick was made and evaluated. This study showed that nicotinamide had anti-microbial effect on staphylococcus.
背景
表皮葡萄球菌是皮肤正常菌群的一部分，可导致痤疮。本研究旨在评估烟酰胺棒剂根除葡萄球菌的疗效。
材料与方法
采用平板法评估对表皮葡萄球菌的抗菌效果。我们选择了五块平板用于烟酰胺，五块用于莫匹罗星。测量并比较抑菌圈。
结果
结果显示烟酰胺棒剂具有抗菌作用，但与莫匹罗星相比明显较弱（P = 0.003）。
结论
制备并评估了烟酰胺棒剂。本研究表明烟酰胺对葡萄球菌有抗菌作用。
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