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降钙素替代治疗可减少降钙素缺乏引起的骨溶解。

Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis.

机构信息

Department of Trauma Surgery, University Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Germany.

出版信息

BMC Musculoskelet Disord. 2011 Aug 15;12:186. doi: 10.1186/1471-2474-12-186.

DOI:10.1186/1471-2474-12-186
PMID:21843355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3171722/
Abstract

BACKGROUND

Periprosthetic osteolysis is a major cause of aseptic loosening in joint arthroplasty. This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice.

METHODS

We used the murine calvarial osteolysis model based on ultra-high molecular weight polyethylene (UHMWPE) particles in 10 C57BL/6J wild-type (WT) mice and twenty Calca -/- mice. The mice were divided into six groups: WT without UHMWPE particles (Group 1), WT with UHMWPE particles (Group 2), Calca -/- mice without UHMWPE particles (Group 3), Calca -/- mice with UHMWPE particles (Group 4), Calca -/- mice without UHMWPE particles and calcitonin substitution (Group 5), and Calca -/- mice with UHMWPE particle implantation and calcitonin substitution (Group 6). Analytes were extracted from serum and urine. Bone resorption was measured by bone histomorphometry. The number of osteoclasts was determined by counting the tartrate-resistant acid phosphatase (TRACP) + cells.

RESULTS

Bone resorption was significantly increased in Calca -/- mice compared with their corresponding WT. The eroded surface in Calca -/- mice with particle implantation was reduced by 20.6% after CT substitution. Osteoclast numbers were significantly increased in Calca -/- mice after particle implantation. Serum OPG (osteoprotegerin) increased significantly after CT substitution.

CONCLUSIONS

As anticipated, Calca -/- mice show extensive osteolysis compared with wild-type mice, and CT substitution reduces particle-induced osteolysis.

摘要

背景

假体周围骨溶解是关节置换术后无菌性松动的主要原因。本研究探讨了在体内情况下降钙素（CT）缺乏和 CT 替代对 Calca -/- 小鼠颗粒诱导性骨溶解的影响。

方法

我们使用基于超高分子量聚乙烯（UHMWPE）颗粒的小鼠颅骨骨溶解模型，在 10 只 C57BL/6J 野生型（WT）小鼠和 20 只 Calca -/- 小鼠中进行研究。将小鼠分为六组：无 UHMWPE 颗粒的 WT 小鼠（第 1 组）、有 UHMWPE 颗粒的 WT 小鼠（第 2 组）、无 UHMWPE 颗粒的 Calca -/- 小鼠（第 3 组）、有 UHMWPE 颗粒的 Calca -/- 小鼠（第 4 组）、无 UHMWPE 颗粒和降钙素替代的 Calca -/- 小鼠（第 5 组）以及有 UHMWPE 颗粒植入和降钙素替代的 Calca -/- 小鼠（第 6 组）。从血清和尿液中提取分析物。通过骨组织形态计量学测量骨吸收。通过计数抗酒石酸酸性磷酸酶（TRACP）+细胞来确定破骨细胞数量。

结果

与相应的 WT 相比，Calca -/- 小鼠的骨吸收明显增加。在 Calca -/- 小鼠中，植入颗粒后，侵蚀表面减少了 20.6%。植入颗粒后，Calca -/- 小鼠的破骨细胞数量显著增加。CT 替代后，血清 OPG（骨保护素）显著增加。

结论

正如预期的那样，与野生型小鼠相比，Calca -/- 小鼠表现出广泛的骨溶解，而 CT 替代可减少颗粒诱导的骨溶解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/6308204cc500/1471-2474-12-186-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/fc051170a09b/1471-2474-12-186-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/3a306484da68/1471-2474-12-186-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/c7e18dbfeffc/1471-2474-12-186-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/e16d969f22e7/1471-2474-12-186-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/2dff4a91b5a9/1471-2474-12-186-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/6308204cc500/1471-2474-12-186-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/fc051170a09b/1471-2474-12-186-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/3a306484da68/1471-2474-12-186-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/c7e18dbfeffc/1471-2474-12-186-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/e16d969f22e7/1471-2474-12-186-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/2dff4a91b5a9/1471-2474-12-186-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93e8/3171722/6308204cc500/1471-2474-12-186-6.jpg

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