Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Environ Toxicol Pharmacol. 2011 Sep;32(2):168-74. doi: 10.1016/j.etap.2011.04.008. Epub 2011 May 5.
To investigate the potential protective effect of C-phycocyanin (PC) on paraquat (PQ)-induced acute lung injury, rats were divided into control, PQ-treated and PQ+PC-treated groups. Rats in PQ-treated group were orally administered with 50mg/kg PQ, and rats in PQ+PC-treated group were intraperitoneally injected with 50mg/kg PC after administration of PQ. At 8, 24, 48 and 72h after treatments, GSH-Px and SOD activities, MDA levels in plasma and BALF, HYP, NF-κB, IκB-α and TNF-α contents in lung tissues were measured. The pathological changes in lung were observed. After treatment with PC, the levels of MDA and the relative contents of NF-κB and TNF-α were significantly decreased, the activities of GSH-Px and SOD and the relative contents of IκB-α were significantly increased. The degree of rat lung damage was obviously reduced in PQ+PC-treated group. The results suggested that PC treatment significantly attenuated PQ-induced acute lung injury.
为了研究 C-藻蓝蛋白（PC）对百草枯（PQ）诱导的急性肺损伤的潜在保护作用，将大鼠分为对照组、PQ 处理组和 PQ+PC 处理组。PQ 处理组大鼠经口给予 50mg/kg PQ，PQ+PC 处理组大鼠在给予 PQ 后经腹腔注射 50mg/kg PC。在处理后 8、24、48 和 72 小时，测量血浆和 BALF 中的 GSH-Px 和 SOD 活性、MDA 水平、肺组织中的 HYP、NF-κB、IκB-α 和 TNF-α含量，并观察肺的病理变化。用 PC 处理后，MDA 水平和 NF-κB 和 TNF-α 的相对含量明显降低，GSH-Px 和 SOD 的活性以及 IκB-α 的相对含量明显增加。PQ+PC 处理组大鼠的肺损伤程度明显减轻。结果表明，PC 处理显著减轻了 PQ 诱导的急性肺损伤。
