天然产物作为 COVID-19 背景下基于家庭的预防和症状管理药物。

Natural products as home-based prophylactic and symptom management agents in the setting of COVID-19.

机构信息

Department of Biosciences, Sri Sathya Sai Institute of Higher Learning, Anantapur, India.

Engineering Technology Department, College of Technology, University of Houston, Sugar Land, Texas, USA.

出版信息

Phytother Res. 2020 Dec;34(12):3148-3167. doi: 10.1002/ptr.6794. Epub 2020 Aug 17.

Abstract

Coronavirus disease (COVID-19) caused by the novel coronavirus (SARS-CoV-2) has rapidly spread across the globe affecting 213 countries or territories with greater than six million confirmed cases and about 0.37 million deaths, with World Health Organization categorizing it as a pandemic. Infected patients present with fever, cough, shortness of breath, and critical cases show acute respiratory infection and multiple organ failure. Likelihood of these severe indications is further enhanced by age as well as underlying comorbidities such as diabetes, cardiovascular, or thoracic problems, as well as due to an immunocompromised state. Currently, curative drugs or vaccines are lacking, and the standard of care is limited to symptom management. Natural products like ginger, turmeric, garlic, onion, cinnamon, lemon, neem, basil, and black pepper have been scientifically proven to have therapeutic benefits against acute respiratory tract infections including pulmonary fibrosis, diffuse alveolar damage, pneumonia, and acute respiratory distress syndrome, as well as associated septic shock, lung and kidney injury, all of which are symptoms associated with COVID-19 infection. This review highlights the potential of these natural products to serve as home-based, inexpensive, easily accessible, prophylactic agents against COVID-19.

摘要

由新型冠状病毒(SARS-CoV-2)引起的冠状病毒病(COVID-19)已迅速在全球范围内蔓延,影响了 213 个国家或地区,确诊病例超过 600 万例,死亡约 37 万例,世界卫生组织将其归类为大流行。受感染的患者会出现发热、咳嗽、呼吸急促等症状,重症患者会出现急性呼吸道感染和多器官衰竭。这些严重症状的可能性会因年龄以及糖尿病、心血管或胸部问题等基础合并症,以及免疫功能低下而进一步增加。目前,尚无治疗药物或疫苗,治疗标准仅限于症状管理。生姜、 turmeric、大蒜、洋葱、肉桂、柠檬、印楝、罗勒和黑胡椒等天然产品已被科学证明对急性呼吸道感染具有治疗作用,包括肺纤维化、弥漫性肺泡损伤、肺炎和急性呼吸窘迫综合征,以及相关的败血症性休克、肺和肾损伤,这些都是与 COVID-19 感染相关的症状。本综述强调了这些天然产品作为基于家庭、廉价、易于获得的 COVID-19 预防剂的潜力。

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