人类 CD1e 对脂质特异性免疫反应的微调。
Fine tuning by human CD1e of lipid-specific immune responses.
机构信息
Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland.
出版信息
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14228-33. doi: 10.1073/pnas.1108809108. Epub 2011 Aug 15.
CD1e is a member of the CD1 family that participates in lipid antigen presentation without interacting with the T-cell receptor. It binds lipids in lysosomes and facilitates processing of complex glycolipids, thus promoting editing of lipid antigens. We find that CD1e may positively or negatively affect lipid presentation by CD1b, CD1c, and CD1d. This effect is caused by the capacity of CD1e to facilitate rapid formation of CD1-lipid complexes, as shown for CD1d, and also to accelerate their turnover. Similar results were obtained with antigen-presenting cells from CD1e transgenic mice in which lipid complexes are assembled more efficiently and show faster turnover than in WT antigen-presenting cells. These effects maximize and temporally narrow CD1-restricted responses, as shown by reactivity to Sphingomonas paucimobilis-derived lipid antigens. CD1e is therefore an important modulator of both group 1 and group 2 CD1-restricted responses influencing the lipid antigen availability as well as the generation and persistence of CD1-lipid complexes.
CD1e 是 CD1 家族的成员，它参与脂质抗原呈递，而不与 T 细胞受体相互作用。它结合溶酶体中的脂质，并促进复杂糖脂的加工，从而促进脂质抗原的编辑。我们发现 CD1e 可能通过 CD1b、CD1c 和 CD1d 正向或负向影响脂质呈递。这种效应是由 CD1e 促进 CD1-脂质复合物快速形成的能力引起的，如 CD1d 所示，也可以加速它们的周转。在 CD1e 转基因小鼠的抗原呈递细胞中也获得了类似的结果，其中脂质复合物组装更有效，并且比 WT 抗原呈递细胞显示更快的周转。这些效应最大化并在时间上缩小了 CD1 限制性反应，如对 Sphingomonas paucimobilis 衍生的脂质抗原的反应所示。因此，CD1e 是影响脂质抗原可用性以及 CD1-脂质复合物的产生和持续时间的组 1 和组 2 CD1 限制性反应的重要调节剂。
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