质体脂质体 II 型 NAD(P)H 醌氧化还原酶对于类异戊二烯醌代谢和维生素 K1 积累是必需的。
Chloroplast lipid droplet type II NAD(P)H quinone oxidoreductase is essential for prenylquinone metabolism and vitamin K1 accumulation.
机构信息
Laboratoire de Physiologie Végétale, Université de Neuchâtel, 2000 Neuchâtel, Switzerland.
出版信息
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14354-9. doi: 10.1073/pnas.1104790108. Epub 2011 Aug 15.
Abstract
Lipid droplets are ubiquitous cellular structures in eukaryotes and are required for lipid metabolism. Little is currently known about plant lipid droplets other than oil bodies. Here, we define dual roles for chloroplast lipid droplets (plastoglobules) in energy and prenylquinone metabolism. The prenylquinones--plastoquinone, plastochromanol-8, phylloquinone (vitamin K(1)), and tocopherol (vitamin E)--are partly stored in plastoglobules. This work shows that NAD(P)H dehydrogenase C1 (NDC1) (At5g08740), a type II NAD(P)H quinone oxidoreductase, associates with plastoglobules. NDC1 reduces a plastoquinone analog in vitro and affects the overall redox state of the total plastoquinone pool in vivo by reducing the plastoquinone reservoir of plastoglobules. Finally, NDC1 is required for normal plastochromanol-8 accumulation and is essential for vitamin K(1) production.
摘要
脂滴是真核生物中普遍存在的细胞结构，对于脂质代谢是必需的。除了油体之外，目前对植物脂滴知之甚少。在这里，我们定义了叶绿体脂滴（质体小球）在能量和类异戊二烯醌代谢中的双重作用。类异戊二烯醌——质体醌、质体醇-8、生育酚醌（维生素 K(1)）和生育酚（维生素 E）——部分储存在质体小球中。这项工作表明，NAD(P)H 脱氢酶 C1（NDC1）（At5g08740），一种 II 型 NAD(P)H 醌氧化还原酶，与质体小球相关联。NDC1 在体外还原质体醌类似物，并通过减少质体小球中质体醌的储存来影响体内总质体醌库的整体氧化还原状态。最后，NDC1 是正常质体醇-8积累所必需的，并且对于维生素 K(1)的产生是必不可少的。
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