Vano-Galvan Sergio, Alvarez-Twose Iván, De las Heras Elena, Morgado J M, Matito Almudena, Sánchez-Muñoz Laura, Plana Maria N, Jaén Pedro, Orfao Alberto, Escribano Luis
Instituto de Estudios de Mastocitosis de Castilla La Mancha, Hospital Virgen del Valle, Carretera de Cobisa s/n, Toledo E-45071, Spain.
Arch Dermatol. 2011 Aug;147(8):932-40. doi: 10.1001/archdermatol.2011.190.
To evaluate dermoscopic features in a group of 127 patients with mastocytosis in the skin and to investigate the relationship between different dermoscopic patterns and other clinical and biological characteristics of the disease.
Clinical and laboratory data were compared among patients with mastocytosis grouped according to the different dermoscopic patterns.
Patients were selected from the Instituto de Estudios de Mastocitosis de Castilla La Mancha and the Department of Dermatology of Hospital Universitario Ramón y Cajal from April 1 through September 30, 2009. Patients Overall, 127 consecutive patients (70 females [55.1%] and 57 males [44.9%]; median age, 17 years; range, 0-81 years) with mastocytosis in the skin were included in the study.
Evaluation of dermoscopic patterns and investigation of potential predictive factors for more symptomatic forms of the disease according to the need for daily antimediator therapy.
Four distinct dermoscopic patterns were observed: yellow-orange blot, pigment network, reticular vascular pattern, and (most frequently) light-brown blot. A reticular vascular pattern was identified in all telangiectasia macular eruptiva and some maculopapular mastocytosis. In turn, all patients with mastocytoma displayed the yellow-orange blot pattern. The reticular vascular dermoscopic pattern was associated with the need for daily antimediator therapy; this pattern, together with serum tryptase levels and plaque-type mastocytosis, represented the best combination of independent factors to predict the need for maintained antimediator therapy.
Dermoscopy is a feasible method for the subclassification of mastocytosis. Of note, a reticular vascular pattern is more frequently associated with the need for antimediator therapy.
评估127例皮肤肥大细胞增多症患者的皮肤镜特征，并研究不同皮肤镜模式与该疾病其他临床和生物学特征之间的关系。
根据不同皮肤镜模式对肥大细胞增多症患者的临床和实验室数据进行比较。
患者选自卡斯蒂利亚-拉曼恰肥大细胞增多症研究所和拉蒙·卡哈尔大学医院皮肤科，时间为2009年4月1日至9月30日。总体而言，127例连续的皮肤肥大细胞增多症患者（70例女性[55.1%]和57例男性[44.9%]；中位年龄17岁；范围0-81岁）纳入研究。
评估皮肤镜模式，并根据每日抗介质治疗的需求，研究该疾病更具症状形式的潜在预测因素。
观察到四种不同的皮肤镜模式：黄橙色斑、色素网、网状血管模式，以及（最常见的）浅棕色斑。在所有斑疹性血管扩张性肥大细胞增多症和一些斑丘疹性肥大细胞增多症中均发现网状血管模式。反过来，所有肥大细胞瘤患者均表现为黄橙色斑模式。网状血管皮肤镜模式与每日抗介质治疗的需求相关；该模式与血清类胰蛋白酶水平和斑块型肥大细胞增多症一起，是预测维持抗介质治疗需求的最佳独立因素组合。
皮肤镜检查是肥大细胞增多症亚分类的一种可行方法。值得注意的是，网状血管模式更常与抗介质治疗的需求相关。
