Department of Molecular Biology and Biotechnology, Sheffield University, Western Bank, Sheffield, UK.
Nat Rev Microbiol. 2011 Aug 16;9(10):737-48. doi: 10.1038/nrmicro2636.
The fungus Candida albicans is often a benign member of the mucosal flora; however, it commonly causes mucosal disease with substantial morbidity and in vulnerable patients it causes life-threatening bloodstream infections. A striking feature of its biology is its ability to grow in yeast, pseudohyphal and hyphal forms. The hyphal form has an important role in causing disease by invading epithelial cells and causing tissue damage. This Review describes our current understanding of the network of signal transduction pathways that monitors environmental cues to activate a programme of hypha-specific gene transcription, and the molecular processes that drive the highly polarized growth of hyphae.
白色念珠菌通常是黏膜菌群中的良性成员；然而，它常引起黏膜疾病，具有相当高的发病率，在脆弱的患者中，它会引起危及生命的血流感染。其生物学的一个显著特征是它能够以酵母、假菌丝和菌丝形式生长。菌丝形式通过侵袭上皮细胞和引起组织损伤在引起疾病方面起着重要作用。这篇综述描述了我们目前对监测环境线索以激活菌丝特异性基因转录程序的信号转导途径网络以及驱动菌丝高度极化生长的分子过程的理解。
