Behrman R E, Masci J R, Nicholas P
Department of Internal Medicine, Mt. Sinai Services, City Hospital Center, Elmhurst, New York 11373.
Rev Infect Dis. 1990 Mar-Apr;12(2):181-90. doi: 10.1093/clinids/12.2.181.
Cryptococcus neoformans is an uncommon but treatable cause of osteomyelitis that affects both normal and immunocompromised hosts. When not considered as a diagnostic possibility, C. neoformans infection may result in increased morbidity. The spectrum of disease at presentation extends from an asymptomatic patient with an osteolytic lesion on radiograph to a patient with signs and symptoms of systemic disease. Once diagnosis has been established (often by closed aspiration), optimal therapy appears to involve a combination of amphotericin B, flucytosine, and surgical debridement.
新型隐球菌是骨髓炎的一种不常见但可治疗的病因，可影响正常宿主和免疫功能低下的宿主。如果不将其视为一种诊断可能性，新型隐球菌感染可能会导致发病率增加。疾病表现范围从影像学检查显示有溶骨性病变的无症状患者到有全身疾病体征和症状的患者。一旦确诊（通常通过闭式穿刺抽吸），最佳治疗似乎包括两性霉素B、氟胞嘧啶和手术清创术联合应用。
