• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

评价酸橙（Bilwa）根的抗炎活性。

Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root.

机构信息

Department of Pharmacology, Jagadguru Sri Shivarathreeshwara Medical College (JSS University), Mysore, India.

出版信息

Indian J Pharmacol. 2011 Jul;43(4):393-7. doi: 10.4103/0253-7613.83108.

DOI:10.4103/0253-7613.83108
PMID:21844992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3153700/
Abstract

AIMS AND OBJECTIVES

The purpose of this study was to evaluate and compare the anti-inflammatory activity of the aqueous root bark extract of Aegle marmelos (Bilwa) in experimental acute and chronic inflammatory animal models.

MATERIALS AND METHODS

Aqueous extract of root bark of Bilwa was prepared and tested for anti-inflammatory activity in albino rats weighing 150-280 grams. The animals were randomly divided into 3 groups of 6 each; one group served as control and other two groups received indomethacin and Bilwa orally 1 hour prior to experimentation. The in vivo anti-inflammatory activity was studied using the acute (Carrageenan induced paw edema) and chronic (Cotton pellet induced granuloma) animal models. Anti-inflammatory activity was expressed as Percent inhibition (PI). Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by Scheffe's post hoc test. P < 0.05 was considered statistically significant.

RESULTS

The PI with indomethacin and Bilwa in carrageenan induced paw edema were 52.7% and 46% and in cotton pellet induced granuloma were 24.7% and 9.2% respectively. Indomethacin showed highly significant anti-inflammatory activity in both the models. However, Bilwa showed highly significant activity in acute model and but a trend of anti-inflammatory activity in chronic model studied.

CONCLUSIONS

As Bilwa showed significant anti-inflammatory activity in the models studied, it can be a promising anti-inflammatory agent.

摘要

目的和目标

本研究旨在评估和比较印度酸角树（Bilwa）水根皮提取物在实验性急性和慢性炎症动物模型中的抗炎活性。

材料和方法

制备 Bilwa 水根皮提取物并在体重 150-280 克的白化大鼠中测试其抗炎活性。将动物随机分为 3 组，每组 6 只；一组作为对照，另外两组在实验前 1 小时口服吲哚美辛和 Bilwa。使用急性（角叉菜胶诱导的爪肿胀）和慢性（棉绒球诱导的肉芽肿）动物模型研究体内抗炎活性。抗炎活性表示为抑制百分比（PI）。使用单因素方差分析（ANOVA）进行统计分析，然后进行 Scheffe 事后检验。P<0.05 被认为具有统计学意义。

结果

在角叉菜胶诱导的爪肿胀中，吲哚美辛和 Bilwa 的 PI 分别为 52.7%和 46%，在棉绒球诱导的肉芽肿中分别为 24.7%和 9.2%。吲哚美辛在两种模型中均表现出高度显著的抗炎活性。然而，Bilwa 在急性模型中表现出显著的抗炎活性，但在研究的慢性模型中表现出抗炎活性的趋势。

结论

由于 Bilwa 在研究的模型中表现出显著的抗炎活性，因此它可能是一种有前途的抗炎药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/dcf787ffb291/IJPharm-43-393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/dcab8f0e6622/IJPharm-43-393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/754649128dc8/IJPharm-43-393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/dcf787ffb291/IJPharm-43-393-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/dcab8f0e6622/IJPharm-43-393-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/754649128dc8/IJPharm-43-393-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2f9/3153700/dcf787ffb291/IJPharm-43-393-g005.jpg

相似文献

1
Evaluation of the anti-inflammatory activity of Aegle marmelos (Bilwa) root.评价酸橙（Bilwa）根的抗炎活性。
Indian J Pharmacol. 2011 Jul;43(4):393-7. doi: 10.4103/0253-7613.83108.
2
Anti-inflammatory effects of Pikad Tri-phol-sa-mut-than remedy, consisting of dried fruits of Aegle marmelos (L.) Corrêa, Coriandrum sativum L., and Morinda citrifolia L.由印度枳椇（Aegle marmelos (L.) Corrêa）、芫荽（Coriandrum sativum L.）和海巴戟（Morinda citrifolia L.）的干燥果实组成的皮卡德三果疗法的抗炎作用
J Ethnopharmacol. 2022 Nov 15;298:115639. doi: 10.1016/j.jep.2022.115639. Epub 2022 Aug 12.
3
Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.枸橼叶抗炎、解热和镇痛特性的研究
J Ethnopharmacol. 2005 Jan 4;96(1-2):159-63. doi: 10.1016/j.jep.2004.09.013.
4
Anti-inflammatory Effect of an Extract of on Experimental Animals.[提取物名称]提取物对实验动物的抗炎作用。 （注：原文中“of an Extract of ”后面缺少具体提取物名称）
Pharmacognosy Res. 2018 Jan-Mar;10(1):104-108. doi: 10.4103/pr.pr_64_17.
5
Anti-inflammatory activity of dried flower extracts of Aegle marmelos in Wistar rats.荜茇花干花提取物对 Wistar 大鼠的抗炎活性。
J Ethnopharmacol. 2014 Feb 12;151(3):1202-1208. doi: 10.1016/j.jep.2013.12.043. Epub 2014 Jan 3.
6
Antiinflammatory evaluation of leaves of Plumeria acuminata.鸡蛋花叶片的抗炎作用评估
BMC Complement Altern Med. 2006 Nov 2;6:36. doi: 10.1186/1472-6882-6-36.
7
Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models.革叶榄仁（Terminalia coriacea（Roxb.）Wight and Arn.）叶的甲醇提取物在急性和慢性模型中表现出抗炎活性。
Med Princ Pract. 2018;27(3):267-271. doi: 10.1159/000488199. Epub 2018 Mar 7.
8
Anti-inflammatory activity of the hexane extract of Byrsonima crassifolia seeds in experimental animal models.厚叶比蒙木种子正己烷提取物在实验动物模型中的抗炎活性。
Altern Ther Health Med. 2013 Jan-Feb;19(1):26-36.
9
Evaluation of anti-inflammatory activity of chloroform extract of Bryonia laciniosa in experimental animal models.刺角瓜氯仿提取物在实验动物模型中的抗炎活性评估。
Biol Pharm Bull. 2003 Sep;26(9):1342-4. doi: 10.1248/bpb.26.1342.
10
Evaluation of anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) extract in laboratory animals.刺天茄提取物在实验动物中的抗炎活性评价。
Anc Sci Life. 2013 Apr;32(4):222-6. doi: 10.4103/0257-7941.131976.

引用本文的文献

1
Exploring pharmacological potential of : integrating traditional knowledge with modern physiology and molecular biology.探索：将传统知识与现代生理学及分子生物学相结合的药理学潜力。
Physiol Mol Biol Plants. 2025 Apr;31(4):521-543. doi: 10.1007/s12298-025-01586-2. Epub 2025 May 22.
2
Characterization of Vancomycin Resistant and Drug Ligand Interaction between of with the Bio-Compounds from .耐万古霉素特性以及[具体内容]与来自[具体来源]的生物化合物之间的药物配体相互作用
J Pharmacopuncture. 2023 Sep 30;26(3):247-256. doi: 10.3831/KPI.2023.26.3.247.
3
(L.) Correa: An Underutilized Fruit with High Nutraceutical Values: A Review.

本文引用的文献

1
Suppression of fertility in male albino rats following the administration of 50% ethanolic extract of Aegle marmelos.给予印度枳50%乙醇提取物后雄性白化大鼠生育力的抑制
Contraception. 2007 Dec;76(6):474-81. doi: 10.1016/j.contraception.2007.08.002. Epub 2007 Nov 9.
2
Antihyperglycemic and antidyslipidemic agent from Aegle marmelos.来自印度枳椇的抗高血糖和抗血脂异常药物。
Bioorg Med Chem Lett. 2007 Mar 15;17(6):1808-11. doi: 10.1016/j.bmcl.2006.12.037. Epub 2006 Dec 15.
3
Antidiarrhoeal evaluation of Aegle Marmelos (Correa) Linn. root extract.
（L.）科雷亚：一种具有高营养保健品价值但尚未充分利用的水果：综述。
Int J Mol Sci. 2022 Sep 17;23(18):10889. doi: 10.3390/ijms231810889.
4
Therapeutic opportunities of edible antiviral plants for COVID-19.可食用抗病毒植物对新冠病毒病的治疗机会
Mol Cell Biochem. 2021 Jun;476(6):2345-2364. doi: 10.1007/s11010-021-04084-7. Epub 2021 Feb 15.
5
Herbal beverages: Bioactive compounds and their role in disease risk reduction - A review.草本饮料：生物活性化合物及其在降低疾病风险中的作用——综述
J Tradit Complement Med. 2018 Aug 9;8(4):451-458. doi: 10.1016/j.jtcme.2017.08.006. eCollection 2018 Oct.
6
Augmentation of hepatoprotective potential of Aegle marmelos in combination with piperine in carbon tetrachloride model in wistar rats.在Wistar大鼠四氯化碳模型中，印度楝与胡椒碱联合使用时对肝脏保护潜力的增强作用。
Chem Cent J. 2018 Aug 20;12(1):94. doi: 10.1186/s13065-018-0463-9.
7
Anti-inflammatory profile of Aegle marmelos (L) Correa (Bilva) with special reference to young roots grown in different parts of India.印度楝（Aegle marmelos (L) Correa (Bilva)）的抗炎特性，特别提及在印度不同地区生长的幼根。
J Ayurveda Integr Med. 2018 Apr-Jun;9(2):90-98. doi: 10.1016/j.jaim.2017.03.006. Epub 2017 Nov 26.
8
Clinical evaluation of Bilvadileha in the management of irritable bowel syndrome.Bilvadileha治疗肠易激综合征的临床评估。
Ayu. 2013 Oct;34(4):368-72. doi: 10.4103/0974-8520.127717.
印度枳椇（柯里亚）林奈根提取物的止泻作用评估。
Phytother Res. 2006 Jan;20(1):82-4. doi: 10.1002/ptr.1804.
4
Expression of estrogen receptor alpha gene in breast cancer cells treated with transcription factor decoy is modulated by Bangladeshi natural plant extracts.用转录因子诱饵处理的乳腺癌细胞中雌激素受体α基因的表达受孟加拉国天然植物提取物的调节。
Oncol Res. 2005;15(2):69-79.
5
Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Corr.枸橼叶抗炎、解热和镇痛特性的研究
J Ethnopharmacol. 2005 Jan 4;96(1-2):159-63. doi: 10.1016/j.jep.2004.09.013.
6
Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties.印度枳椇的抗糖尿病活性及其与抗氧化特性的关系。
Indian J Physiol Pharmacol. 2004 Jan;48(1):81-8.
7
Evaluation of the radioprotective effect of bael leaf (Aegle marmelos) extract in mice.印度枳椇叶提取物对小鼠辐射防护作用的评估。
Int J Radiat Biol. 2004 Apr;80(4):281-90. doi: 10.1080/09553000410001679776.
8
[On the mechanism of cortisone inhibition of connective tissue proliferation].[关于可的松抑制结缔组织增生的机制]
Experientia. 1950 Dec 15;6(12):469-71. doi: 10.1007/BF02154110.
9
In vitro antiviral activity of bael (Aegle marmelos Corr) upon human coxsackieviruses B1-B6.
J Commun Dis. 2002 Jun;34(2):88-99.
10
Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs.角叉菜胶诱导大鼠后爪水肿作为抗炎药物的一种测定方法。
Proc Soc Exp Biol Med. 1962 Dec;111:544-7. doi: 10.3181/00379727-111-27849.