More Shraddha K, Lande Anirudha A, Jagdale Priti G, Adkar Prafulla P, Ambavade Shirishkumar D
Department of Pharmacology, JSPM's Jayawantrao Sawant College of Pharmacy and Research, Hadapsar, Pune, Maharashtra, India.
Anc Sci Life. 2013 Apr;32(4):222-6. doi: 10.4103/0257-7941.131976.
Solanum xanthocarpum Schrad and Wendl (Kaṇṭakāri) is a diffuse herb with prickly stem, traditionally used for the treatment of inflammation and one in the group of daśamūla (group of ten herbs) herbs commonly used drug in Ayurveda.
In continuation of search for potent natural anti-inflammatory agents, the present research work was planned to evaluate the anti-inflammatory activity of ethanol extract of S. xanthocarpum whole plant.
The ethanol extract was evaluated at dose 10, 30 and 100 mg/kg p.o. in rats.
Using pharmacological screening models carrageenan induced rat paw edema, histamine induced rat paw edema and cotton pellet granuloma in rats.
Data obtained was analyzed statistically using analysis of variance followed by post-hoc Dunnett test, P < 0.05 is considered as statistically significant.
Acute treatment didn't show anti-inflammatory activity against carrageenan and histamine induced paw edema. However, administration of 100 mg/kg p.o for 7 day reduced the granuloma formation in cotton pellet granuloma model.
Present results support the traditional use of plant for anti-inflammatory activity. In brief, the results provide scientific pharmacological basis for the therapeutic use of S. xanthocarpum.
黄果茄（Solanum xanthocarpum Schrad and Wendl）是一种茎上有刺的蔓生草本植物，传统上用于治疗炎症，是阿育吠陀医学中常用的十大草药之一。
为了继续寻找有效的天然抗炎剂，本研究计划评估黄果茄全株乙醇提取物的抗炎活性。
以10、30和100mg/kg的口服剂量在大鼠中评估乙醇提取物。
使用角叉菜胶诱导的大鼠足爪肿胀、组胺诱导的大鼠足爪肿胀和大鼠棉球肉芽肿等药理学筛选模型。
对获得的数据进行方差分析，然后进行事后Dunnett检验，P<0.05被认为具有统计学意义。
急性处理对角叉菜胶和组胺诱导的足爪肿胀未显示抗炎活性。然而，连续7天口服100mg/kg可减少棉球肉芽肿模型中的肉芽肿形成。
目前的结果支持该植物用于抗炎活性的传统用途。简而言之，这些结果为黄果茄的治疗应用提供了科学的药理学依据。
