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日光浴沙龙与皮肤癌。

Tanning salons and skin cancer.

机构信息

Centre de Recherche en Cancérologie de Lyon, UMR Inserm U1052 - CNRS U5286, Centre Léon Bérard, 28, rue Laënnec, 69373, Lyon Cedex 08, France.

出版信息

Photochem Photobiol Sci. 2012 Jan;11(1):30-7. doi: 10.1039/c1pp05186e. Epub 2011 Aug 15.

Abstract

Indoor tanning has substantially grown in USA and Europe, more especially in the sun-deprived Northern countries, but also in more sunny countries such as Queensland, Australia. Several studies have specifically addressed the prevalence of sunbed use by children and adolescents in Northern Europe and in the USA, and showed that up to 40-50% of teenagers 15-18 years old had ever used indoor tanning, the highest figures being observed among girls in Scandinavia and Minnesota. Indoor tanning among adults is mostly prevalent in age classes younger than 45. Epidemiological studies have shown that exposure to sunbeds increases the risk of both melanoma and non-melanoma skin cancers: a meta-analysis of 19 studies published before 2006 showed that ever-use of sunbeds was positively associated with melanoma (summary relative risk, 1.15; 95% CI, 1.00-1.31), and first exposure before 35 years of age significantly increased melanoma risk (7 studies, RR = 1.75; 95% CI, 1.35-2.26). Further epidemiological data documented the links between artificial UV tanning and melanoma: two large case-control studies in Minnesota and Australia yielded higher melanoma risks for ever use of sunbeds: 1.74 (95%CI, 1.42-2.14) and 1.41 (95%CI, 1.01-1.96) respectively, risk increasing with greater use and earlier age at first use. The most compelling evidence derives from a large cohort of Norwegian and Swedish women which showed that melanoma risk increased with accumulating exposure (RR for solarium use ≥1 time per month in two or three decades, 10-39 years, 2.37 (95%CI, 1.37-4.08)). In addition, the analysis of a melanoma epidemic observed in Iceland between 1995 and 2002, on the trunk of women younger than 50, pointed out the possible role of the explosion of exposure to sunbeds in this country after 1985. Exposure to artificial ultraviolet is a risk factor for melanoma. Risk appears modest in the general population, but concentrates in the population that started sunbed use before the age of 35; the risk attributable to sunbed use in melanoma patients younger than 30 may be as high as 43 to 76%. Of particular concern is the use of sunbeds by adolescents. Use of sunbeds should be strongly discouraged, and banned under the age of 18.

摘要

室内晒黑在美国和欧洲大幅增长,尤其是在阳光匮乏的北方国家,但在阳光更充足的国家如澳大利亚昆士兰州也有所增加。一些研究专门探讨了北欧和美国儿童和青少年使用日光浴床的流行情况,结果表明,多达 40-50%的 15-18 岁青少年曾经使用过室内晒黑,其中斯堪的纳维亚和明尼苏达州的女孩比例最高。成年人中,使用室内晒黑的主要是年龄在 45 岁以下的人群。流行病学研究表明,暴露于日光浴床会增加患黑色素瘤和非黑色素瘤皮肤癌的风险:2006 年之前发表的 19 项研究的荟萃分析表明,曾经使用日光浴床与黑色素瘤呈正相关(综合相对风险,1.15;95%置信区间,1.00-1.31),而 35 岁之前首次接触日光浴床会显著增加黑色素瘤风险(7 项研究,RR=1.75;95%置信区间,1.35-2.26)。进一步的流行病学数据记录了人工紫外线晒黑与黑色素瘤之间的联系:明尼苏达州和澳大利亚的两项大型病例对照研究表明,曾经使用日光浴床的黑色素瘤风险更高:1.74(95%CI,1.42-2.14)和 1.41(95%CI,1.01-1.96),使用频率越高,首次使用年龄越小,风险越高。最有力的证据来自挪威和瑞典女性的大型队列研究,该研究表明,黑色素瘤风险随着暴露量的累积而增加(在 20 至 30 年内每月使用日光浴床≥1 次的风险比,10-39 岁,2.37(95%CI,1.37-4.08))。此外,对 1995 年至 2002 年期间在冰岛观察到的一种黑色素瘤流行情况进行的分析表明,在该国 1985 年后,暴露于日光浴床的人数增加,可能是导致这种情况的原因之一。暴露于人工紫外线是黑色素瘤的一个风险因素。在普通人群中,风险似乎较低,但集中在 35 岁之前开始使用日光浴床的人群中;在 30 岁以下的黑色素瘤患者中,由于使用日光浴床而导致的风险可能高达 43%至 76%。特别令人关注的是青少年使用日光浴床。应强烈劝阻使用日光浴床,并禁止 18 岁以下的人使用。

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