与即将发生流产相关的 kisspeptin-10 水平：一项初步研究。
Association of kisspeptin-10 levels with abortus imminens: a preliminary study.
机构信息
Department of Obstetric and Gynecology, Firat Universitesi Hastanesi Kadin Dogum Anabilim Dali, 23119 Elazig, Turkey.
出版信息
Arch Gynecol Obstet. 2012 Mar;285(3):649-53. doi: 10.1007/s00404-011-2061-0. Epub 2011 Aug 17.
PURPOSE
To investigate the association between kisspeptin 10 (Kp-10) levels and early pregnancy bleeding and perinatal outcome.
METHODS
A total of 20 pregnant women with the complaint of vaginal bleeding during 7-18 gestational weeks and 20 healthy gestational week matched pregnant women were included in the study. Maternal plasma Kp-10 levels were measured with the enzyme immunoassay method. Adverse pregnancy outcomes like intrauterine growth restriction, preterm delivery, preeclampsia and low birth weight were evaluated in both groups.
RESULTS
Maternal plasma Kp-10 levels (p = 0.01) and birth weight (p = 0.06) were found to be lower in women with bleeding. Intrauterine growth restriction, preterm delivery and intrauterine exitus were noted more commonly in women with bleeding (10 vs. 0%, 25 vs. 15% and 20 vs. 0%, p = 0.08). Preeclampsia were developed in 5% of both groups. Kp-10 levels showed positive correlation with gestational week (p = 0.02) and ALT levels (p = 0.02).
CONCLUSION
[corrected] Kp-10 levels were found lower in women with early pregnancy bleeding.
目的
探讨 kisspeptin 10（Kp-10）水平与早期妊娠出血及围产结局的关系。
方法
纳入 20 例妊娠 7-18 周有阴道出血症状的孕妇和 20 例同期健康妊娠的孕妇作为研究对象。采用酶联免疫吸附法测定母体外周血 Kp-10 水平。评估两组孕妇的不良妊娠结局，如宫内生长受限、早产、子痫前期和低出生体重儿。
结果
出血组孕妇的母体外周血 Kp-10 水平（p = 0.01）和出生体重（p = 0.06）均较低。出血组孕妇宫内生长受限、早产和宫内死亡的发生率更高（10%比 0%、25%比 15%和 20%比 0%，p = 0.08）。两组孕妇子痫前期的发生率均为 5%。Kp-10 水平与妊娠周数呈正相关（p = 0.02），与 ALT 水平呈正相关（p = 0.02）。
结论
早期妊娠出血孕妇的 Kp-10 水平较低。
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