Khafif R A, DeLima C, Silverberg A, Frankel R
Department of Surgery, Maimonides Medical Center, Brooklyn, NY.
Arch Intern Med. 1990 May;150(5):956-9.
The phenomenon of calciphylaxis as defined by Selye is a condition of hypersensitivity that results in acute local calcification of various organs, with a whole host of morbid processes. Nephrocalcinosis and cutaneous calcifications have long been recognized in patients with chronic renal failure, but they have not often been reported in acute hyperparathyroidism or other causes of calcium-phosphate metabolism aberrations. The pathogenesis is not clear, and both the sensitizer and challenging agent in the hypersensitivity theory are often elusive, though hypercalcemia is the most consistent factor. The clinical features vary according to the organs affected and often mimic a gamut of more common conditions. Treatment is primarily supportive, with specific measures only possible when a sensitizer or challenger is identified. Correction of the hypercalcemia is, however, imperative. It is important to recognize this rare condition to avoid the more serious end results often reported.
塞利所定义的钙过敏现象是一种超敏反应状态，会导致各个器官出现急性局部钙化，并引发一系列病态过程。肾钙质沉着症和皮肤钙化在慢性肾衰竭患者中早已为人所知，但在急性甲状旁腺功能亢进症或其他钙磷代谢异常的病因中却较少有报道。其发病机制尚不清楚，尽管高钙血症是最一致的因素，但超敏反应理论中的致敏原和激发剂往往难以捉摸。临床特征因受累器官而异，常常类似于一系列更常见的病症。治疗主要是支持性的，只有在确定致敏原或激发剂时才可能采取具体措施。然而，纠正高钙血症是至关重要的。认识到这种罕见病症很重要，以避免经常报道的更严重的最终结果。
