通过 Cu(I)-双恶唑啉催化实现羰基的对映选择性 α-芳基化反应。
Enantioselective α-arylation of carbonyls via Cu(I)-bisoxazoline catalysis.
机构信息
Merck Center for Catalysis at Princeton University, New Jersey 08544, United States.
出版信息
J Am Chem Soc. 2011 Sep 7;133(35):13782-5. doi: 10.1021/ja206050b. Epub 2011 Aug 17.
Abstract
The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.
摘要
使用二芳基碘鎓盐和铜催化的组合，实现了内酯和酰基恶唑烷酮的对映选择性 α-芳基化。这些温和的催化条件为烯醇化 α-羰基苄基立体中心的对映选择性构建和保留提供了一种新策略，这是生产药物的有价值的合成子。
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