Merck Center for Catalysis at Princeton University, New Jersey 08544, United States.
J Am Chem Soc. 2011 Sep 7;133(35):13782-5. doi: 10.1021/ja206050b. Epub 2011 Aug 17.
The enantioselective α-arylation of both lactones and acyl oxazolidones has been accomplished using a combination of diaryliodonium salts and copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-carbonyl benzylic stereocenters, a valuable synthon for the production of medicinal agents.
使用二芳基碘鎓盐和铜催化的组合，实现了内酯和酰基恶唑烷酮的对映选择性 α-芳基化。这些温和的催化条件为烯醇化 α-羰基苄基立体中心的对映选择性构建和保留提供了一种新策略，这是生产药物的有价值的合成子。
