National Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
J Anim Physiol Anim Nutr (Berl). 2012 Dec;96(6):955-61. doi: 10.1111/j.1439-0396.2011.01205.x. Epub 2011 Aug 16.
The current study was carried out to determine the effects of alpha-lipoic acid (LA) supplementation during late-gestation and lactation on antioxidative ability and performance of sows and their nursing piglets. A total of 160 multiparous sows were randomly allocated to four treatments with 40 replicates per treatment according to parity number and backfat (BF) thickness. Sows were fed 1 of 4 diets from day 85 of gestation to day 21 of lactation. Diets were control without LA; 400 ppm LA supplementation; 600 ppm LA supplementation; and 800 ppm LA supplementation. BF thickness of sows was determined on day 85 and 110 of gestation and days 1 and 21 of lactation. Piglet bodyweight was measured at birth, days 7, 14 and 21. Blood samples were obtained from the sows, and average daily feed intake (ADFI) of the sows during lactation was recorded. There were no differences in BF thickness or ADFI among treatment groups. Dietary LA supplementation resulted in a decrease in blood urea nitrogen (p < 0.01) concentration at days 110 of gestation. Dietary 800 ppm LA increased serum glutathione peroxidase (GSH-Px) activity (p < 0.05) and reduced maleic dialdehyde levels (p < 0.01) of sows compared with the control diet at days 21 of lactation. Alpha-lipoic acid supplementation increased the birthweight and weaning weight of piglets (p < 0.01) compared with the control group. Weight gains of piglets from sows fed the 800 ppm LA diets were greater (p < 0.01) between days 7 and 14 compared with piglets from control sows. Weight gains of piglets from sows fed the LA-supplemented diets were greater between days 14 and 21 (p < 0.05) and between days 1 and 21 (p < 0.01) compared with piglets from control-fed sows. In conclusion, the results indicate that antioxidant LA was effective in enhancing antioxidant enzymes activity and improving the performance of sows and their nursing piglets.
本研究旨在确定妊娠后期和哺乳期补充α-硫辛酸 (LA) 对母猪及其哺乳仔猪的抗氧化能力和生产性能的影响。总共 160 头经产母猪根据胎次和背膘（BF）厚度随机分配到 4 个处理组，每个处理组有 40 个重复。母猪从妊娠第 85 天到哺乳期第 21 天饲喂 4 种日粮中的 1 种。日粮处理为：不添加 LA 的对照组；400 ppm LA 补充组；600 ppm LA 补充组；800 ppm LA 补充组。在妊娠第 85 天和第 110 天以及哺乳期第 1 天和第 21 天测定母猪的 BF 厚度。仔猪在出生时、第 7 天、第 14 天和第 21 天进行体重测量。记录哺乳期母猪的平均日采食量（ADFI）。各组母猪的 BF 厚度或 ADFI 无差异。日粮 LA 补充导致妊娠第 110 天母猪血液尿素氮（BUN）浓度降低（p < 0.01）。与对照组相比，日粮 800 ppm LA 增加了哺乳期第 21 天母猪血清谷胱甘肽过氧化物酶（GSH-Px）活性（p < 0.05）和降低了丙二醛水平（p < 0.01）。与对照组相比，LA 补充增加了仔猪的初生重和断奶重（p < 0.01）。饲喂 800 ppm LA 日粮的母猪所产仔猪的 7-14 天和 14-21 天的增重（p < 0.01）均大于对照组。与对照组相比，饲喂 LA 补充日粮的母猪所产仔猪的 14-21 天和 1-21 天的增重（p < 0.05）和 1-21 天的增重（p < 0.01）均较大。综上所述，结果表明抗氧化剂 LA 能有效提高母猪及其哺乳仔猪的抗氧化酶活性和生产性能。
