Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, In der Schornau 23–25, D-44892 Bochum, Germany.
J Neurol Sci. 2011 Nov 15;310(1-2):231-6. doi: 10.1016/j.jns.2011.07.020. Epub 2011 Aug 16.
The hypokinetic dysarthria of Parkinson's disease (PD) has been defined as a multidimensional impairment leading to abnormalities in speech breathing, phonation, articulation and prosody. The aspect of prosody can be subdivided into further dimensions, as for example stress and accentuation, intonation variability and speech rate and regularity. According to available data from literature and findings of our own published studies, the present review illuminates the concept that inconstancies of speech fluency in PD are characterized by modifications of the arrangement of speech pauses and by a tendency of pace acceleration in the course of the performance. Furthermore, on the level of single utterances, Parkinsonian speakers feature significant difficulties to steadily repeat single syllables without accelerating or slowing down the pace as we were able to show in a series of published investigations. Evidence from literature and our own work justifies the hypothesis that the characteristic abnormalities in speech articulatory rate and regularity might serve as a marker of disease progression in PD.
帕金森病（PD）的运动障碍性构音障碍已被定义为一种多维障碍，导致言语呼吸、发声、发音和韵律异常。韵律方面可以进一步细分为其他维度，例如重音和强调、语调变异性和语速和规律性。根据文献中的现有数据和我们自己发表的研究结果，本综述阐明了这样一个概念，即在 PD 中，言语流畅性的不稳定性的特点是言语停顿安排的改变，以及在表现过程中加速的趋势。此外，在单个话语的水平上，帕金森病患者在稳定地重复单个音节时会遇到显著的困难，而不会加速或减慢语速，正如我们在一系列已发表的研究中所展示的那样。来自文献和我们自己工作的证据支持这样一个假设，即言语发音率和规律性的特征异常可能是 PD 疾病进展的一个标志物。
