Department of Neurology, University Clinic Bonn, Bonn, Germany.
Mov Disord. 2012 Feb;27(2):316-9. doi: 10.1002/mds.24030. Epub 2011 Nov 22.
The aim of the current study was to test the hypothesis of a fundamental impairment of vocal pacing in patients with spinocerebellar ataxia and Parkinson's disease.
Thirty-one patients with spinocerebellar ataxia, 42 patients with Parkinson's disease, and 43 healthy controls had to repeat a single syllable at a self-chosen isochronous pace. The coefficient of variance for interval length and the change in interval length with successive utterances were used to describe pace stability.
Ataxic and parkinsonian patients both showed a significant instability of vocal pace performance. Ataxic speakers featured difficulties in keeping the pace immediately from the beginning of the task, whereas parkinsonian patients accelerated the pace in the course of the performance. The results support differential roles of cerebellar and basal ganglia pathways in motor speech performance.
Cerebellar function may be required for the general precision of interval timing, whereas basal ganglia rather serve to maintain rhythm stability over time.
本研究旨在检验小脑性共济失调和帕金森病患者在发声时距控制方面存在固有缺陷的假说。
31 名小脑性共济失调患者、42 名帕金森病患者和 43 名健康对照者需要按照自己选择的等时节奏重复一个单音节。用间隔长度的变异系数和连续发音时间隔长度的变化来描述节奏稳定性。
共济失调和帕金森病患者的发声节奏表现都显著不稳定。共济失调患者在任务开始时就难以保持节奏，而帕金森病患者在表现过程中则加快了节奏。结果支持小脑和基底神经节通路在运动言语表现中发挥不同作用。
小脑功能可能对间隔时间的总体精度有要求，而基底神经节则负责随时间维持节奏稳定性。
