Department of Surgery, Leiden University Medical Centre, The Netherlands.
Eur J Surg Oncol. 2011 Oct;37(10):829-35. doi: 10.1016/j.ejso.2011.04.012. Epub 2011 Aug 17.
The most common complication after breast cancer surgery is seroma formation. It is a source of significant morbidity and discomfort. Many articles have been published describing risk factors and preventive measures. The aim of this paper is to provide a systematic review of studies and reports on risk factors and preventive measures. Surgery lies at the core of seroma formation; therefore focus will be placed on surgical ways of reducing seroma.
A computer assisted medline search was carried out, followed by manual retrieval of relevant articles found in the reference listings of original articles.
136 relevant articles were reviewed. Though the level of evidence remain varied several factors, type of dissection, tools with which dissection is carried out, reduction of dead space, suction drainage, use of fibrin glue and octreotide usage, have been found to correlate with seroma formation and have been shown to significantly reduce seroma rates.
Seroma formation after breast cancer surgery cannot be avoided at present. There are however several methods to minimize seroma and associated morbidity. Future research should be directed towards the best ways of reducing seroma by combining proven methods.
乳腺癌手术后最常见的并发症是血清肿形成。它是导致发病率和不适的主要原因。有许多文章描述了风险因素和预防措施。本文旨在对有关风险因素和预防措施的研究和报告进行系统综述。手术是血清肿形成的核心，因此将重点放在减少血清肿的手术方法上。
进行了计算机辅助的 Medline 搜索，然后手动检索原始文章参考文献中找到的相关文章。
共回顾了 136 篇相关文章。尽管证据水平仍然存在差异，但几种因素，如解剖类型、进行解剖的工具、减少死腔、抽吸引流、使用纤维蛋白胶和奥曲肽，与血清肿形成相关，并已被证明可显著降低血清肿发生率。
目前乳腺癌手术后血清肿的形成无法避免。但是有几种方法可以最大限度地减少血清肿和相关发病率。未来的研究应致力于通过结合已证明的方法来寻找减少血清肿的最佳方法。
