Ranchod M, Bissell M
Arch Pathol Lab Med. 1979 Mar;103(3):139-42.
We report a case of pulmonary alveolar proteinosis (PAP) and cytomegalovirus (CMV) infection occurring in a 5-year-old boy with acute lymphoblastic leukemia. The association of PAP and CMV infection is rare, but the possible etiologic role of CMV in the production of PAP is raised. Pulmonary alveolar proteinosis is being reported with increasing frequency in immunocompromised patients, and this disease may be difficult to distinguish from other causes of diffuse lung disease both clinically and radiologically. Pulmonary alveolar proteinosis, either alone or in combination with CMV infection, should therefore be considered in the differential diagnosis of diffuse lung disease in these cases.
我们报告了一例发生在一名5岁急性淋巴细胞白血病男孩身上的肺泡蛋白沉积症（PAP）合并巨细胞病毒（CMV）感染的病例。PAP与CMV感染的关联较为罕见，但CMV在PAP发生中的可能病因作用被提出。免疫功能低下患者中肺泡蛋白沉积症的报告频率越来越高，并且这种疾病在临床和放射学上可能难以与其他弥漫性肺部疾病的病因相区分。因此，在这些病例中弥漫性肺部疾病的鉴别诊断中应考虑肺泡蛋白沉积症，无论是单独存在还是与CMV感染合并存在。
