自杀未遂者的脑脊液和血浆催产素水平、童年创伤和再次受害的作用。
CSF and plasma oxytocin levels in suicide attempters, the role of childhood trauma and revictimization.
作者信息
Chatzittofis Andreas, Nordström Peter, Uvnäs-Moberg Kerstin, Asberg Marie, Jokinen Jussi
出版信息
Neuro Endocrinol Lett. 2014;35(3):213-7.
OBJECTIVE
Some studies have reported an inverse relationship between childhood adversity and oxytocin levels. The purpose of this study was to assess the relationship between CSF and plasma oxytocin levels and lifetime trauma history in suicide attempters. We hypothesised lower CSF and plasma oxytocin levels in suicide attempters with high exposure to interpersonal violence and negative childhood emotional climate.
METHODS
28 medication free suicide attempters participated in the study. CSF and plasma morning basal levels of oxytocin were assessed with specific radioimmunoassays. The Karolinska Interpersonal Violence Scale (KIVS) was used to elicit lifetime trauma history and revictimization status and the childhood emotional climate factor was derived from the socialization subscale of the Karolinska Scales of Personality.
RESULTS
Correlations between exposure to interpersonal violence as a child and as an adult and CSF and plasma oxytocin levels were not significant. Revictimized suicide attempters had significantly lower plasma oxytocin levels and more negative childhood emotional climate compared to non-revictimized suicide attempters.
CONCLUSIONS
Our results indicate a complex relationship between life time trauma and the oxytocin system.
目的
一些研究报告了童年逆境与催产素水平之间的负相关关系。本研究的目的是评估自杀未遂者脑脊液和血浆中催产素水平与终生创伤史之间的关系。我们假设，在遭受高人际暴力暴露和童年负面情绪氛围的自杀未遂者中，脑脊液和血浆催产素水平较低。
方法
28名未服用药物的自杀未遂者参与了本研究。采用特定放射免疫分析法评估脑脊液和血浆中催产素的早晨基础水平。使用卡罗林斯卡人际暴力量表（KIVS）来获取终生创伤史和再次受害状况，童年情绪氛围因素来自卡罗林斯卡人格量表的社会化子量表。
结果
儿童期和成年期人际暴力暴露与脑脊液和血浆催产素水平之间的相关性不显著。与未再次受害的自杀未遂者相比，再次受害的自杀未遂者血浆催产素水平显著较低，童年情绪氛围更负面。
结论
我们的结果表明终生创伤与催产素系统之间存在复杂关系。
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