人脑中的催产素和血管升压素：用于转化医学的社会神经肽。
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine.
机构信息
Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Square J5, D-68159 Mannheim, Germany.
出版信息
Nat Rev Neurosci. 2011 Aug 19;12(9):524-38. doi: 10.1038/nrn3044.
The neuropeptides oxytocin (OXT) and arginine vasopressin (AVP) are evolutionarily highly conserved mediators in the regulation of complex social cognition and behaviour. Recent studies have investigated the effects of OXT and AVP on human social interaction, the genetic mechanisms of inter-individual variation in social neuropeptide signalling and the actions of OXT and AVP in the human brain as revealed by neuroimaging. These data have advanced our understanding of the mechanisms by which these neuropeptides contribute to human social behaviour. OXT and AVP are emerging as targets for novel treatment approaches--particularly in synergistic combination with psychotherapy--for mental disorders characterized by social dysfunction, such as autism, social anxiety disorder, borderline personality disorder and schizophrenia.
神经肽催产素（OXT）和精氨酸血管加压素（AVP）是调节复杂社会认知和行为的在进化上高度保守的介质。最近的研究调查了 OXT 和 AVP 对人类社会互动的影响、社会神经肽信号传递中个体间变异的遗传机制，以及神经影像学揭示的 OXT 和 AVP 在人类大脑中的作用。这些数据增进了我们对这些神经肽促进人类社会行为的机制的理解。OXT 和 AVP 正在成为新的治疗方法的靶点——特别是与心理治疗协同结合——用于以社会功能障碍为特征的精神障碍，如自闭症、社交焦虑障碍、边缘型人格障碍和精神分裂症。
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