Cassoni Andrea, Brauner Edoardo, Pucci Resi, Terenzi Valentina, Mangini Nicolò, Battisti Andrea, Della Monaca Marco, Ciolfi Alessandro, Laudoni Federico, Di Carlo Stefano, Valentini Valentino
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome; Via Caserta 6, 00161 Rome, Italy.
Oncological and Reconstructive Maxillo-Facial Surgery Unit, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy.
Cancers (Basel). 2020 Jul 18;12(7):1948. doi: 10.3390/cancers12071948.
Head and Neck osteosarcoma is an uncommon disease. Hitherto, the treatment is surgical resection and survival is influenced by the presence of free margins. However, the dimension of the resection may represent a hurdle for an adequate Quality of Life (QOL). Maxillofacial district is a narrow space where the function, esthetics and patient's relational skills fit together like the gears of a clock. The functional results depend on the type of reconstruction and prosthetic rehabilitation that are both important to guarantee a good aesthetic result and finally increase the patient's self-esteem. This study aims to report our experience about head and neck (HN) osteosarcoma focusing the attention on reconstructive and dental-rehabilitative problems. It is a retrospective study all patients were surgically treated in our department. Subjects with histological diagnosis of HN osteosarcoma, treated between 2005 and 2017 were included. The demographic characteristics, surgical treatment, eventually secondary reconstruction and prosthetic rehabilitation, performed in the same department, have been collected. The QOL was assessed through the EORTC QLQ-H&N35 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Head and Neck 35) questionnaire. Fifteen patients were enrolled, eight received a free flap microsurgical reconstruction. Dental rehabilitation was performed in five cases and a mobile prosthesis was always delivered. Eighteen implants were inserted in fibula bones for three patients; highly porous implants were used.
头颈部骨肉瘤是一种罕见疾病。迄今为止,治疗方法是手术切除,切缘情况会影响生存率。然而,手术切除范围可能对患者的生活质量(QOL)构成障碍。颌面区域空间狭窄,功能、美观和患者社交技能如同钟表的齿轮般相互关联。功能恢复情况取决于重建类型和修复性康复,这两者对于保证良好的美学效果以及最终提升患者自尊都很重要。本研究旨在报告我们对头颈部(HN)骨肉瘤的治疗经验,重点关注重建和牙齿修复问题。这是一项回顾性研究,所有患者均在我科接受手术治疗。纳入2005年至2017年间接受治疗且组织学诊断为HN骨肉瘤的患者。收集了患者的人口统计学特征、手术治疗情况、最终的二期重建和修复性康复情况,这些均在同一科室进行。通过欧洲癌症研究与治疗组织生活质量问卷-头颈部35(EORTC QLQ-H&N35)对生活质量进行评估。共纳入15例患者,8例接受了游离皮瓣显微外科重建。5例患者进行了牙齿修复,均配备了可摘义齿。3例患者在腓骨上植入了18颗种植体;使用的是高度多孔种植体。