Trimbos Institute, Netherlands Institute of Mental Health and Addiction, Da Costakade 45, Postbox 725, 3500 AS, Utrecht, The Netherlands.
Trials. 2011 Aug 19;12:196. doi: 10.1186/1745-6215-12-196.
Depression is a common condition whose first onset is usually in late adolescence or early adulthood. Internet-based interventions are an effective treatment approach to depression. The aim of this study is to investigate the effectiveness of a Dutch online cognitive-behavioural group course known as Master Your Mood (Grip op Je Dip) for young people reporting depressive symptoms. Secondary research questions involve maintenance of effect at 6 months, mediators, and predictors of better outcomes.
We will conduct a randomised controlled trial (RCT) in which 244 young people aged 16-25 are randomly allocated to the Grip op Je Dip (GOJD) online group course or to a waiting list control group. The participants will be recruited from the general population. The primary outcome measure will be the severity of depressive symptoms according to the Center for Epidemiological Studies Depression Scale (CES-D). Other outcomes will include anxiety (Hospital Anxiety and Depression Scale-Anxiety, HADS) and mastery (Mastery Scale). Assessments will take place in both groups at baseline and three months later. Effect maintenance will be studied in the GOJD group six months after baseline, with missing data imputed using the expectation-maximisation method. Mediators and predictors of better outcomes will also be identified.
The trial should add to the body of knowledge on the effectiveness of Internet-based interventions for depression. To our knowledge, this will be the first RCT on an online group intervention in this field.
NTR1694.
抑郁症是一种常见的疾病，其首次发病通常在青少年晚期或成年早期。基于互联网的干预措施是治疗抑郁症的一种有效方法。本研究旨在调查一种名为“掌控情绪”（Grip op Je Dip）的荷兰在线认知行为小组课程对报告抑郁症状的年轻人的疗效。次要研究问题包括 6 个月时的效果维持、中介因素和更好结果的预测因素。
我们将进行一项随机对照试验（RCT），将 244 名 16-25 岁的年轻人随机分配到“掌控情绪”（GOJD）在线小组课程或候补名单对照组。参与者将从普通人群中招募。主要结局指标将是根据流行病学研究中心抑郁量表（CES-D）评估的抑郁症状严重程度。其他结果将包括焦虑（医院焦虑和抑郁量表-焦虑，HADS）和掌握感（掌握量表）。在基线和 3 个月后，两组都将进行评估。在基线后 6 个月，将对 GOJD 组进行效果维持研究，并使用期望最大化法对缺失数据进行插补。还将确定更好结果的中介因素和预测因素。
该试验应有助于增加基于互联网的干预措施治疗抑郁症的有效性知识体系。据我们所知，这将是该领域首次关于在线小组干预的 RCT。
NTR1694。
