Rao Mohandas K, Rao Muddanna S, Rao Gurumadhva S
Department of Anatomy, Melaka Manipal Medical College, Manipal 576 104, India. Tel. +91 (820) 2922631 / 2922519. Fax. +91 (820) 2571905. E-mail:
Neurosciences (Riyadh). 2007 Jul;12(3):236-41.
To investigate the role of Centella asiatica (CeA) fresh leaf extract treatment on the behavior, especially learning and memory, of adult rats.
Adult rats (2.5 months old) were fed with 2, 4, and 6 ml/kg body of fresh leaf extract of CeA for 2, 4, and 6 weeks. After the treatment period the rats were subjected to spatial learning (T-Maze) and passive avoidance tests along with age matched normal and saline control rats. The data were compared with those of age matched control rats. The study was conducted at the Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India between December 2001 and February 2005.
The rats treated with a higher dose (6 ml) of CeA showed improvement in spatial learning performance, namely, increased (p<0.001) number of alternations and decreased (p<0.001) percentage bias during spontaneous alternation test and increased (p<0.001) percentage bias during rewarded alternation test. They also showed enhanced memory retention power, namely, less (p<0.001) time spent in the small compartment during the retention period of passive avoidance test.
This indicates that treatment with higher doses of CeA fresh leaf extract enhances learning ability and memory retention power in adult rats.
研究积雪草鲜叶提取物对成年大鼠行为，尤其是学习和记忆的作用。
给2.5月龄成年大鼠分别灌胃2、4和6 ml/kg体重的积雪草鲜叶提取物，持续2、4和6周。处理期结束后，对这些大鼠以及年龄匹配的正常大鼠和生理盐水对照大鼠进行空间学习（T迷宫）和被动回避试验。将数据与年龄匹配的对照大鼠的数据进行比较。该研究于2001年12月至2005年2月在印度卡纳塔克邦马尼帕尔市马尼帕尔高等教育学院马六甲马尼帕尔医学院进行。
用较高剂量（6 ml）积雪草提取物处理的大鼠在空间学习能力方面有所改善，即在自发交替试验中交替次数增加（p<0.001）、偏差百分比降低（p<0.001），在奖励交替试验中偏差百分比增加（p<0.001）。它们还表现出增强的记忆保持能力，即在被动回避试验的保持期内在小隔室中停留的时间更短（p<0.001）。
这表明用较高剂量的积雪草鲜叶提取物处理可增强成年大鼠的学习能力和记忆保持能力。
