Keil U
Ruhr-Universität Bochum, Abteilung für Sozialmedizin und Epidemiologie, Bochum.
Arzneimittelforschung. 1990 Mar;40(3A):388-94.
Epidemiologic cohort studies such as Framingham, Tecumseh, Evans County and the Multiple Risk Factor Intervention Trial Cohort Study have shown, that hypercholesterolemia, hypertension and cigarette smoking are the strongest predictors for cardiovascular diseases and especially for coronary heart disease. From the intervention studies of the last two decades it has been learn that reductions of the risk factors hypercholesterolemia and hypertension have led to the predicted reductions in cardiovascular and all cause mortality. Two strategies are available for the prevention of hypercholesterolemia and hypertension: The population strategy and the high risk strategy. With regard to cholesterol and blood pressure the population approach strives for the shifting of the respective population distributions to the left i.e. to lower values. The high risk strategy on the other hand restricts itself to the 10-20% of the population with very high values. A comparison of the population and high risk strategy shows, that only the population strategy is radical in that only this strategy is capable to eliminate the causes of the incidence of hypercholesterolemia and hypertension. The high risk strategy on the other hand is unable to influence the total distribution curve. Population strategy and high risk strategy should be seen as complementary. To further reduce mortality and morbidity from cardiovascular diseases in the Federal Republic of Germany the following public health programs and health policy strategies must be applied: a) Reinforcement of the National High Blood Pressure Education Program. b) Establishment of a National High Cholesterol Education Program. c) Nationwide Anti-smoking Campaigns and Programs.(ABSTRACT TRUNCATED AT 250 WORDS)
诸如弗明汉姆、蒂卡姆西、埃文斯县和多重危险因素干预试验队列研究等流行病学队列研究表明,高胆固醇血症、高血压和吸烟是心血管疾病尤其是冠心病最强的预测因素。从过去二十年的干预研究中可以得知,降低高胆固醇血症和高血压等危险因素已导致心血管疾病和全因死亡率如预期那样下降。预防高胆固醇血症和高血压有两种策略:人群策略和高危策略。就胆固醇和血压而言,人群策略致力于将各自人群的分布向左移动,即向更低值移动。另一方面,高危策略仅针对10%至20%具有极高值的人群。对人群策略和高危策略的比较表明,只有人群策略是彻底的,因为只有该策略能够消除高胆固醇血症和高血压发病的原因。另一方面,高危策略无法影响总体分布曲线。人群策略和高危策略应被视为互补的。为了进一步降低德意志联邦共和国心血管疾病的死亡率和发病率,必须实施以下公共卫生计划和卫生政策策略:a)加强国家高血压教育计划。b)建立国家高胆固醇教育计划。c)全国范围内的禁烟运动和计划。(摘要截于250字)