Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada.
PLoS One. 2011;6(8):e23298. doi: 10.1371/journal.pone.0023298. Epub 2011 Aug 17.
Radioligand positron emission tomography (PET) with dual scan paradigms can provide valuable insight into changes in synaptic neurotransmitter concentration due to experimental manipulation. The residual t-test has been utilized to improve the sensitivity of the t-test in PET studies. However, no further development of statistical tests using residuals has been proposed so far to be applied in cases when there are more than two conditions. Here, we propose the residual f-test, a one-way analysis of variance (ANOVA), and examine its feasibility using simulated [(11)C]raclopride PET data. We also re-visit data from our previously published [(11)C]raclopride PET study, in which 10 individuals underwent three PET scans under different conditions. We found that the residual f-test is superior in terms of sensitivity than the conventional f-test while still controlling for type 1 error. The test will therefore allow us to reliably test hypotheses in the smaller sample sizes often used in explorative PET studies.
放射性配体正电子发射断层扫描 (PET) 采用双扫描范式，可以深入了解由于实验操作而导致的突触神经递质浓度的变化。残差 t 检验已被用于提高 PET 研究中 t 检验的灵敏度。然而，到目前为止，还没有提出进一步开发使用残差的统计检验，以应用于存在两个以上条件的情况。在这里，我们提出了残差 F 检验，一种单因素方差分析（ANOVA），并使用模拟 [(11)C]raclopride PET 数据来检验其可行性。我们还重新分析了我们之前发表的 [(11)C]raclopride PET 研究的数据，其中 10 名个体在不同条件下进行了三次 PET 扫描。我们发现，残差 F 检验在灵敏度方面优于传统的 F 检验，同时仍能控制第一类错误。因此，该检验将使我们能够在探索性 PET 研究中经常使用的较小样本量中可靠地检验假设。
