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树突介导的高度 PEG 化嵌段共聚物的自组装：一种模块化的纳米载体平台。

Dendron-mediated self-assembly of highly PEGylated block copolymers: a modular nanocarrier platform.

机构信息

Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S. Wood St. Chicago, IL 60612, USA.

出版信息

Chem Commun (Camb). 2011 Oct 7;47(37):10302-4. doi: 10.1039/c1cc14331j. Epub 2011 Aug 22.

DOI:10.1039/c1cc14331j
PMID:21858356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3190671/
Abstract

PEGylated dendron coils (PDCs) were investigated as a novel potential nanocarrier platform. PDCs self-assembled into micelles at lower CMCs than linear copolymer counterparts by 1-2 orders of magnitude, due to the unique architecture of dendrons. MD simulations also supported thermodynamically favourable self-assembly mediated by dendrons.

摘要

聚乙二醇化树枝状聚合物线圈（PDCs）被研究为一种新型的潜在纳米载体平台。PDCs 通过 1-2 个数量级的自组装成胶束，低于线性共聚物对照物，这是由于树枝状聚合物的独特结构。分子动力学模拟也支持了树枝状聚合物介导的热力学有利的自组装。

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