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韩国农村地区糖尿病视网膜病变的患病率及相关因素:忠州代谢性疾病队列研究。

Prevalence and associated factors of diabetic retinopathy in rural Korea: the Chungju metabolic disease cohort study.

机构信息

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

出版信息

J Korean Med Sci. 2011 Aug;26(8):1068-73. doi: 10.3346/jkms.2011.26.8.1068. Epub 2011 Jul 30.

Abstract

This study was aimed to investigate the prevalence of diabetic retinopathy and its associated factors in rural Korean patients with type 2 diabetes. A population-based, cross-sectional diabetic retinopathy survey was conducted from 2005 to 2006 in 1,298 eligible participants aged over 40 yr with type 2 diabetes identified in a rural area of Chungju, Korea. Diabetic retinopathy was diagnosed by a practicing ophthalmologist using funduscopy. The overall prevalence of diabetic retinopathy in the population was 18% and proliferative or severe non-proliferative form was found in 5.0% of the study subjects. The prevalence of retinopathy was 6.2% among those with newly diagnosed type 2 diabetes and 2.4% of them had a proliferative or severe non-proliferative diabetic retinopathy. The odds ratio of diabetic retinopathy increased with the duration of diabetes mellitus (5-10 yr: 5.2- fold; > 10 yr: 10-fold), postprandial glucose levels (> 180 mg/dL: 2.5-fold), and HbA1c levels (every 1% elevation: 1.34-fold). The overall prevalence of diabetic retinopathy in rural Korean patients was similar to or less than that of other Asian group studies. However, the number of patients with proliferative or severe non-proliferative diabetic retinopathy was still high and identified more frequently at the time of diagnosis. This emphasizes that regular screening for diabetic retinopathy and more aggressive management of glycemia can reduce the number of people who develop diabetic retinopathy.

摘要

本研究旨在调查韩国农村 2 型糖尿病患者糖尿病视网膜病变的患病率及其相关因素。2005 年至 2006 年,在韩国忠州市的一个农村地区,对年龄在 40 岁以上的 1298 名符合条件的 2 型糖尿病患者进行了一项基于人群的横断面糖尿病视网膜病变调查。糖尿病视网膜病变由一名执业眼科医生通过眼底镜诊断。该人群的糖尿病视网膜病变总患病率为 18%,其中增生性或严重非增生性病变占研究对象的 5.0%。新诊断为 2 型糖尿病患者的视网膜病变患病率为 6.2%,其中 2.4%的患者患有增生性或严重非增生性糖尿病视网膜病变。糖尿病视网膜病变的几率随着糖尿病病程的延长而增加(5-10 年:5.2 倍;> 10 年:10 倍)、餐后血糖水平(> 180mg/dL:2.5 倍)和 HbA1c 水平(每升高 1%:1.34 倍)。韩国农村 2 型糖尿病患者的糖尿病视网膜病变总患病率与其他亚洲人群研究相似或较低。然而,增生性或严重非增生性糖尿病视网膜病变的患者人数仍然较高,且在诊断时更常见。这强调了定期筛查糖尿病视网膜病变和更积极地控制血糖可以减少发生糖尿病视网膜病变的人数。

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