Wu Jingyang, Geng Jin, Liu Limin, Teng Weiping, Liu Lei, Chen Lei
Department of Ophthalmology, The First Hospital of China Medical University, Shenyang 110001, China.
Key Laboratory of Endocrine Diseases of Liaoning Province, The First Hospital of China Medical University, Shenyang 110001, China.
J Ophthalmol. 2015;2015:326209. doi: 10.1155/2015/326209. Epub 2015 Mar 18.
Diabetic retinopathy (DR) is the leading cause of visual impairment and blindness in working-aged people. Several studies have suggested that glomerular filtration rate (GFR) was correlated with DR. This is a hospital-based study and the aim of it was to examine the relationship between the GFR and DR in patients with type 2 diabetes mellitus (T2DM). We used CKD-EPI equation to estimate GFR and SPSS 19.0 and EmpowerStats software to assess their relationship. Among the 1613 participants (aged 54.75 ± 12.19 years), 550 (34.1%) patients suffered from DR. The multivariate analysis revealed that the risk factors for DR include age (P < 0.001, OR = 0.940), duration of diabetes (P < 0.001, OR = 1.163), hemoglobin A1c (P = 0.007, OR = 1.224), systolic blood pressure (P < 0.001, OR = 1.032), diastolic blood pressure (P = 0.007, OR = 0.953), high density lipoprotein cholesterol (P = 0.024, OR = 3.884), and eGFR (P = 0.010, OR = 0.973). Through stratified analysis and saturation effect analysis, our data suggests that eGFR of 99.4 mL/min or lower might imply the early stage of DR in diabetic patients. Thus, the evaluation of eGFR has clinical significance for the early diagnosis of DR.
糖尿病视网膜病变（DR）是劳动年龄人群视力损害和失明的主要原因。多项研究表明，肾小球滤过率（GFR）与DR相关。这是一项基于医院的研究，其目的是探讨2型糖尿病（T2DM）患者中GFR与DR之间的关系。我们使用CKD-EPI方程估算GFR，并使用SPSS 19.0和EmpowerStats软件评估它们之间的关系。在1613名参与者（年龄54.75±12.19岁）中，550名（34.1%）患者患有DR。多因素分析显示，DR的危险因素包括年龄（P<0.001，OR=0.940）、糖尿病病程（P<0.001，OR=1.163）、糖化血红蛋白（P=0.007，OR=1.224）、收缩压（P<0.001，OR=1.032）、舒张压（P=0.007，OR=0.953）、高密度脂蛋白胆固醇（P=0.024，OR=3.884）和估算肾小球滤过率（eGFR）（P=0.010，OR=0.973）。通过分层分析和饱和效应分析，我们的数据表明，eGFR为99.4 mL/min或更低可能意味着糖尿病患者DR的早期阶段。因此，eGFR评估对DR的早期诊断具有临床意义。
