Neis M M, Wurpts G, Wilbers L, Merk H F
Hautklinik - Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Aachen, Deutschland.
Hautarzt. 2011 Sep;62(9):677-82. doi: 10.1007/s00105-011-2160-7.
Specific immunotherapy (SIT) of hymenoptera venom allergy, in particular, has become an example for the effectiveness of the treatment of IgE-mediated allergic diseases. In vitro diagnostic procedures and the measurement of serum tryptase for risk assessment are well-established in the process of diagnose finding and therapy preparation. For monitoring and validation of the effectiveness of the SIT, however, in vitro diagnostic procedures remain controversial. Potentially useful approaches include detection of specific IgE, specific IgG4, basophile activation - represented by the CD 63 expression - and the lymphocyte proliferation and its IL10 release. Preliminary data suggest that the latter method appear appropriate, whereas the detection of basophile activation did not produce definite results.
膜翅目毒液过敏的特异性免疫疗法（SIT）尤其已成为IgE介导的过敏性疾病治疗有效性的一个范例。在诊断发现和治疗准备过程中，体外诊断程序以及用于风险评估的血清类胰蛋白酶测量已得到充分确立。然而，对于监测和验证SIT的有效性，体外诊断程序仍存在争议。潜在有用的方法包括检测特异性IgE、特异性IgG4、以CD 63表达为代表的嗜碱性粒细胞活化以及淋巴细胞增殖及其IL10释放。初步数据表明后一种方法似乎合适，而嗜碱性粒细胞活化的检测并未产生明确结果。
