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[结节病患者的原发性免疫性血小板减少症]

[Primary immune thrombocytopenia in a patient with sarcoidosis].

作者信息

Dąbrowska Marta, Krenke Rafał, Maskey-Warzęchowska Marta, Boguradzki Piotr, Waszczuk-Gajda Anna, Jędrzejczak Wiesław Wiktor, Caban Paweł, Chazan Ryszarda

机构信息

Katedra i Klinika Chorób Wewnętrznych, Pneumonologii i Alergologii Warszawskiego Uniwersytetu Medycznego.

出版信息

Pneumonol Alergol Pol. 2011;79(5):371-6.

Abstract

Sarcoidosis is a disease with a strongly variable clinical manifestation. It may be associated with various autoimmune diseases but hematological manifestations have rarely been observed. The prevalence of thrombocytopenia in patients with sarcoidosis has been estimated at 2%, about 1% of patients with thrombocytopenia have been diagnosed with sarcoidosis We present a case of sarcoidosis associated with primary immune thrombocytopenia of an abrupt and severe onset. Three potential patomechanisms of thrombocytopenia in sarcoidosis: 1) autoantibody related platelet destruction, 2) bone marrow involvement, and 3) hipersplenism are discussed.

摘要

结节病是一种临床表现差异很大的疾病。它可能与多种自身免疫性疾病相关,但血液学表现很少见。据估计,结节病患者血小板减少症的患病率为2%,约1%的血小板减少症患者被诊断为结节病。我们报告一例结节病合并急性重症原发性免疫性血小板减少症的病例。本文讨论了结节病血小板减少症的三种潜在发病机制:1)自身抗体相关的血小板破坏,2)骨髓受累,3)脾功能亢进。

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