Department of Oncology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
Cell Biochem Funct. 2011 Oct;29(7):582-8. doi: 10.1002/cbf.1791. Epub 2011 Aug 22.
Brain metastasis frequently occurs in cancer patients and is associated with a poor prognosis. We previously reported that S100B was highly expressed in PC14/B, a specific brain metastatic lung adenocarcinoma cell line, which suggests that it is associated with brain metastasis of lung cancer. However, the role of S100B in brain metastasis remains to be elucidated. In this study, using PC14/B cell line, we found that siRNA mediated depletion of S100B in PC14/B cells led to notable differences in cell proliferation, apoptosis, cell cycle progression, colony formation ability, cell migratory and invasive activity compared with the mock-transfected cells. Therefore, our data suggest that S100B promotes the brain metastasis of lung adenocarcinoma by promoting cell proliferation, preventing apoptosis and increasing cell migration and invasion.
脑转移经常发生在癌症患者中，预后不良。我们之前报道 S100B 在 PC14/B 中高表达，PC14/B 是一种特定的脑转移肺腺癌细胞系，这表明它与肺癌的脑转移有关。然而，S100B 在脑转移中的作用仍有待阐明。在这项研究中，我们使用 PC14/B 细胞系发现，与 mock 转染细胞相比，siRNA 介导的 PC14/B 细胞中 S100B 的耗竭导致细胞增殖、凋亡、细胞周期进程、集落形成能力、细胞迁移和侵袭活性的显著差异。因此，我们的数据表明 S100B 通过促进细胞增殖、防止凋亡以及增加细胞迁移和侵袭来促进肺腺癌的脑转移。
