School of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
J Microencapsul. 2011;28(7):595-604. doi: 10.3109/02652048.2011.557748. Epub 2011 Aug 23.
Chitosan-coated nanoliposomes containing etofenprox or alpha-cypermethrin prepared by ultrasonic homogenization maintained a size distribution in the nanometre range. Nanoliposomes were constructed using different types and concentrations of chitosan to regulate the mean size and surface charge. As the chitosan concentration (0.1-0.5%, w/v) and the degree of deacetylation increased, surface charge also increased. The encapsulation efficiency and release profile were measured by gas chromatography. Encapsulation efficiency decreased slightly as chitosan concentration increased (0.1-0.5%, w/v). As the intrinsic surface charge or concentration of the coating material increased, the release period of the entrapped core material was extended (chitosans A and B; 0.1 and 0.3%, w/v). The results indicate that diverse preparation conditions could affect the physicochemical properties and release profile of the resulting nanocarrier systems.
采用超声匀化法制备的载乙氧基虫螨腈或α-氯氰菊酯壳聚糖纳米脂质体，粒径分布在纳米范围内。通过使用不同类型和浓度的壳聚糖来构建纳米脂质体，以调节平均粒径和表面电荷。随着壳聚糖浓度（0.1-0.5%，w/v）和脱乙酰度的增加，表面电荷也随之增加。通过气相色谱法测量包封效率和释放曲线。随着壳聚糖浓度（0.1-0.5%，w/v）的增加，包封效率略有下降。随着包被材料的固有表面电荷或浓度的增加，包封芯材的释放周期延长（壳聚糖 A 和 B，0.1 和 0.3%，w/v）。结果表明，不同的制备条件会影响所得纳米载体系统的理化性质和释放曲线。
