Oliveira Alves Mônica Ghislaine, Kitakawa Dárcio, Carvalho Yasmin Rodarte, Guimarães Cabral Luiz Antonio, Almeida Janete Dias
Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, Universidade Estadual Paulista - UNESP, São José dos Campos, São Paulo, Brazil.
J Med Case Rep. 2011 Aug 23;5:406. doi: 10.1186/1752-1947-5-406.
Necrotizing sialometaplasia is a benign, self-limiting and rare inflammatory disease which, on clinical and histological examination, mimics malignant neoplasms.
We report the case of a healthy 25-year-old Caucasian woman with a three-week history of a painless lump on her hard palate. Oral examination revealed a nodule consisting of two lobules on the right side that measured 2.5 cm. Her mucosa was normal in color and a fluctuant area was detected in the posterior region upon palpation. Our patient was submitted to incisional biopsy and histopathological examination. The histological diagnosis was necrotizing sialometaplasia. The lesion had healed spontaneously after 30 days, with observed signs of involution of the nodule.
Histopathological examination is necessary for the diagnosis of necrotizing sialometaplasia because the clinical features of this condition can mimic other diseases, particularly malignant neoplasms.
坏死性涎腺化生是一种良性、自限性且罕见的炎症性疾病，在临床和组织学检查中易与恶性肿瘤相混淆。
我们报告一例健康的25岁白种女性病例，其硬腭出现无痛性肿块已有三周。口腔检查发现右侧有一个由两个小叶组成的结节，大小为2.5厘米。其黏膜颜色正常，触诊时在后部区域发现一个波动区。该患者接受了切开活检和组织病理学检查。组织学诊断为坏死性涎腺化生。30天后病变自行愈合，结节出现消退迹象。
由于坏死性涎腺化生的临床特征可与其他疾病尤其是恶性肿瘤相类似，因此组织病理学检查对于诊断该病很有必要。
