Active DNA demethylation by oxidation and repair.
作者信息
Gong Zhizhong, Zhu Jian-Kang
机构信息
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
出版信息
Cell Res. 2011 Dec;21(12):1649-51. doi: 10.1038/cr.2011.140. Epub 2011 Aug 23.
Abstract
摘要
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本文引用的文献
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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA.Tet 介导的哺乳动物 DNA 中 5-羧基胞嘧啶的形成及其由 TDG 切除。
Science. 2011 Sep 2;333(6047):1303-7. doi: 10.1126/science.1210944. Epub 2011 Aug 4.
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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.Tet 蛋白可以将 5-甲基胞嘧啶转化为 5-醛基胞嘧啶和 5-羧基胞嘧啶。
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Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair.胸腺嘧啶 DNA 糖基化酶是通过链接的脱氨碱基切除修复进行主动 DNA 去甲基化所必需的。
Cell. 2011 Jul 8;146(1):67-79. doi: 10.1016/j.cell.2011.06.020. Epub 2011 Jun 30.
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Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells.胚胎干细胞中 5-羟甲基胞嘧啶的全基因组图谱绘制。
Nature. 2011 May 19;473(7347):394-7. doi: 10.1038/nature10102. Epub 2011 May 8.
5
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.Tet1 羟化酶在小鼠胚胎干细胞中对 5hmC、5mC 和基因表达的全基因组调控。
Mol Cell. 2011 May 20;42(4):451-64. doi: 10.1016/j.molcel.2011.04.005. Epub 2011 Apr 21.
6
Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.TET1 介导的 5-甲基胞嘧啶羟化促进成年大脑中的活性 DNA 去甲基化。
Cell. 2011 Apr 29;145(3):423-34. doi: 10.1016/j.cell.2011.03.022. Epub 2011 Apr 14.
7
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.TET1 和羟甲基胞嘧啶在转录和 DNA 甲基化保真度中的作用。
Nature. 2011 May 19;473(7347):343-8. doi: 10.1038/nature10066. Epub 2011 Apr 13.
8
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.Tet1 在小鼠胚胎干细胞转录调控中的双重功能。
Nature. 2011 May 19;473(7347):389-93. doi: 10.1038/nature09934. Epub 2011 Mar 30.
9
Active DNA demethylation: many roads lead to Rome.主动 DNA 去甲基化：条条大路通罗马。
Nat Rev Mol Cell Biol. 2010 Sep;11(9):607-20. doi: 10.1038/nrm2950. Epub 2010 Aug 4.
10
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.Tet 蛋白在 5mC 向 5hmC 的转化、胚胎干细胞自我更新和内细胞团特化中的作用。
Nature. 2010 Aug 26;466(7310):1129-33. doi: 10.1038/nature09303.
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