The State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
Langmuir. 2011 Oct 4;27(19):12134-42. doi: 10.1021/la202096x. Epub 2011 Sep 1.
A new method for the fabrication of Fe(3)O(4) nanoparticles enveloped by polymeric nanocapsules is proposed. This method is characterized by combining a double emulsification with the interfacial coprecipitation of iron salts to form Fe(3)O(4)/polymer composite nanocapsules in a single step. To demonstrate the viability of this approach, methoxy poly(ethylene glycol)-poly(lactide) (MePLEG) was chosen as the shell material for Fe(3)O(4)/MePLEG nanocapsules. In addition to the versatility offered for fabricating nanocapsules with different shell materials, the method was found to be convenient for adjusting the magnetite content of the nanocapsules from 0 to 43%. In addition to their confirmed T(2)-weighted magnetic resonance imaging (MRI) enhancement, the resultant composite nanocapsules display much more obvious acoustic responses than MePLEG nanocapsules in an acoustic investigation. Furthermore, the low toxicity of these composite nanocapsules, as confirmed by our study, combined with their magnetic and acoustic properties ensure that these composite nanocapsules have great potential in acting as ultrasonic/MRI dual contrast agents.
提出了一种新的方法来制备被聚合物纳米胶囊包裹的 Fe(3)O(4)纳米粒子。该方法的特点是将双重乳化与铁盐的界面共沉淀相结合，一步形成 Fe(3)O(4)/聚合物复合纳米胶囊。为了证明这种方法的可行性，选择甲氧基聚乙二醇-聚（乳酸）（MePLEG）作为 Fe(3)O(4)/MePLEG 纳米胶囊的壳材料。除了为制备具有不同壳材料的纳米胶囊提供的多功能性外，还发现该方法便于从 0 到 43%调整纳米胶囊的磁铁矿含量。除了已经证实的 T2 加权磁共振成像（MRI）增强作用外，在声学研究中，所得的复合纳米胶囊比 MePLEG 纳米胶囊显示出更明显的声响应。此外，我们的研究证实了这些复合纳米胶囊的低毒性，以及它们的磁性和声学特性，确保了这些复合纳米胶囊在作为超声/MRI 双重对比剂方面具有巨大的潜力。
