Moreira-Teixeira Liliana S, Georgi Nicole, Leijten Jeroen, Wu Ling, Karperien Marcel
Endocr Dev. 2011;21:102-115. doi: 10.1159/000328140. Epub 2011 Aug 22.
Cartilage tissue engineering is the art aimed at repairing defects in the articular cartilage which covers the bony ends in the joints. Since its introduction in the early 1990s of the past century, cartilage tissue engineering using ACI has been used in thousands of patients to repair articular cartilage defects. This review focuses on emerging strategies to improve cartilage repair by incorporating fundamental knowledge of developmental and cell biology in the design of optimized strategies for cell delivery at the defect site and to locally stimulate cartilage repair responses.
软骨组织工程是一门旨在修复覆盖关节骨端的关节软骨缺损的技术。自上世纪90年代初问世以来，采用自体软骨细胞移植（ACI）的软骨组织工程已应用于数千名患者，以修复关节软骨缺损。本综述重点关注通过将发育生物学和细胞生物学的基础知识纳入优化的细胞递送策略设计中，在缺损部位局部刺激软骨修复反应，从而改善软骨修复的新兴策略。
