Olvera Dinorath, Daly Andrew, Kelly Daniel John
Trinity Centre for Bioengineering, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
Department of Mechanical and Manufacturing Engineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
Methods Mol Biol. 2015;1340:279-87. doi: 10.1007/978-1-4939-2938-2_20.
A key goal of functional cartilage tissue engineering is to develop constructs with mechanical properties approaching those of the native tissue. Herein we describe a number of tests to characterize the mechanical properties of tissue engineered cartilage. Specifically, methods to determine the equilibrium confined compressive (or aggregate) modulus, the equilibrium unconfined compressive (or Young's) modulus, and the dynamic modulus of tissue engineered cartilaginous constructs are described. As these measurements are commonly used in both the articular cartilage mechanics literature and the cartilage tissue engineering literature to describe the mechanical functionality of cartilaginous constructs, they facilitate comparisons to be made between the properties of native and engineered tissues.
功能性软骨组织工程的一个关键目标是开发出机械性能接近天然组织的构建体。在此，我们描述了一些用于表征组织工程软骨机械性能的测试。具体而言，介绍了测定组织工程软骨构建体的平衡受限压缩（或聚合）模量、平衡无约束压缩（或杨氏）模量和动态模量的方法。由于这些测量方法在关节软骨力学文献和软骨组织工程文献中都常用于描述软骨构建体的机械功能，它们有助于对天然组织和工程组织的性能进行比较。
