• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

肠道微生物群:挑战免疫学。

The gut microbiota: challenging immunology.

机构信息

Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Nat Rev Immunol. 2011 Aug 26;11(10):636-7. doi: 10.1038/nri3061.

DOI:10.1038/nri3061
PMID:21869815
Abstract

For several decades the intestinal microbiota was mainly studied by those investigating infections and diseases associated with gut health, usually from a microbiology point of view. In the past few years, however, it has become apparent that the intestinal microbiota has widespread implications in the field of immunology, and researchers are being compelled to explain how the microbiota contributes to and/or affects their studies.

摘要

几十年来,肠道微生物群主要由研究与肠道健康相关的感染和疾病的人员进行研究,通常从微生物学的角度进行研究。然而,在过去的几年中,肠道微生物群在免疫学领域具有广泛的影响已经变得明显,研究人员被迫解释微生物群如何有助于和/或影响他们的研究。

相似文献

1
The gut microbiota: challenging immunology.肠道微生物群:挑战免疫学。
Nat Rev Immunol. 2011 Aug 26;11(10):636-7. doi: 10.1038/nri3061.
2
Unravelling the effects of the environment and host genotype on the gut microbiome.解析环境和宿主基因型对肠道微生物组的影响。
Nat Rev Microbiol. 2011 Apr;9(4):279-90. doi: 10.1038/nrmicro2540.
3
Functional Classification of the Gut Microbiota: The Key to Cracking the Microbiota Composition Code: Functional classifications of the gut microbiota reveal previously hidden contributions of indigenous gut bacteria to human health and disease.肠道微生物群的功能分类:破解微生物组组成密码的关键:肠道微生物群的功能分类揭示了本土肠道细菌对人类健康和疾病的先前隐藏贡献。
Bioessays. 2017 Dec;39(12). doi: 10.1002/bies.201700032. Epub 2017 Oct 4.
4
Diet, gut microbiota and immune responses.饮食、肠道微生物群和免疫反应。
Nat Immunol. 2011 Jan;12(1):5-9. doi: 10.1038/ni0111-5.
5
The role of gut microbiota in immune homeostasis and autoimmunity.肠道微生物群在免疫稳态和自身免疫中的作用。
Gut Microbes. 2012 Jan-Feb;3(1):4-14. doi: 10.4161/gmic.19320. Epub 2012 Jan 1.
6
Control of pathogens and pathobionts by the gut microbiota.肠道微生物群对病原体和条件致病菌的控制。
Nat Immunol. 2013 Jul;14(7):685-90. doi: 10.1038/ni.2608.
7
Early development of intestinal microbiota: implications for future health.肠道微生物菌群的早期发育:对未来健康的影响。
Gastroenterol Clin North Am. 2012 Dec;41(4):717-31. doi: 10.1016/j.gtc.2012.08.001. Epub 2012 Oct 1.
8
Intestinal commensal microbes as immune modulators.肠道共生微生物作为免疫调节剂。
Cell Host Microbe. 2012 Oct 18;12(4):496-508. doi: 10.1016/j.chom.2012.09.009.
9
Mining the human gut microbiota for effector strains that shape the immune system.从人类肠道微生物群中挖掘出影响免疫系统的效应菌株。
Immunity. 2014 Jun 19;40(6):815-23. doi: 10.1016/j.immuni.2014.05.012.
10
The role of the microbiome in immune cell development.微生物群落在免疫细胞发育中的作用。
Ann Allergy Asthma Immunol. 2014 Dec;113(6):593-8. doi: 10.1016/j.anai.2014.08.020.

引用本文的文献

1
Intestinal Microbiota and Vaccinations: A Systematic Review of the Literature.肠道微生物群与疫苗接种:文献系统综述
Vaccines (Basel). 2025 Mar 12;13(3):306. doi: 10.3390/vaccines13030306.
2
Vaccination with an HIV T-cell immunogen induces alterations in the mouse gut microbiota.接种 HIV T 细胞免疫原会引起小鼠肠道微生物群的改变。
NPJ Biofilms Microbiomes. 2022 Dec 30;8(1):104. doi: 10.1038/s41522-022-00368-y.
3
Gut Barrier Damage and Gut Translocation of Pathogen Molecules in Lupus, an Impact of Innate Immunity (Macrophages and Neutrophils) in Autoimmune Disease.

本文引用的文献

1
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis.NLRP6 炎性体调节结肠微生物生态和结肠炎风险。
Cell. 2011 May 27;145(5):745-57. doi: 10.1016/j.cell.2011.04.022. Epub 2011 May 12.
2
Colonic microbiota alters host susceptibility to infectious colitis by modulating inflammation, redox status, and ion transporter gene expression.肠道微生物群通过调节炎症、氧化还原状态和离子转运体基因表达改变宿主对感染性结肠炎的易感性。
Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G39-49. doi: 10.1152/ajpgi.00509.2010. Epub 2011 Mar 31.
3
'Gut health': a new objective in medicine?
狼疮中的肠道屏障损伤和病原体分子的肠道易位,固有免疫(巨噬细胞和中性粒细胞)在自身免疫性疾病中的作用。
Int J Mol Sci. 2022 Jul 26;23(15):8223. doi: 10.3390/ijms23158223.
4
Genomic, microbial and environmental standardization in animal experimentation limiting immunological discovery.动物实验中的基因组、微生物和环境标准化限制了免疫学发现。
BMC Immunol. 2020 Sep 2;21(1):50. doi: 10.1186/s12865-020-00380-x.
5
The Gut Microbiota of the Egyptian Mongoose as an Early Warning Indicator of Ecosystem Health in Portugal.埃及狐蝠的肠道微生物群作为葡萄牙生态系统健康的早期预警指标。
Int J Environ Res Public Health. 2020 Apr 29;17(9):3104. doi: 10.3390/ijerph17093104.
6
Housing influences tissue cytokine levels and the fecal bacterial community structure in rats.居住环境会影响大鼠的组织细胞因子水平和粪便细菌群落结构。
J Funct Foods. 2017 Dec;39:306-311. doi: 10.1016/j.jff.2017.10.021. Epub 2017 Nov 2.
7
Signaling Through gp130 Compromises Suppressive Function in Human FOXP3 Regulatory T Cells.gp130 信号转导损害人 FOXP3+调节性 T 细胞的抑制功能。
Front Immunol. 2019 Jul 18;10:1532. doi: 10.3389/fimmu.2019.01532. eCollection 2019.
8
Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota.小鼠 T 细胞诱导结肠炎的差异易感性:肠道微生物群的作用。
Inflamm Bowel Dis. 2018 Jan 18;24(2):361-379. doi: 10.1093/ibd/izx014.
9
Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms.激素避孕与 HIV-1 感染:生物学机制。
Endocr Rev. 2018 Feb 1;39(1):36-78. doi: 10.1210/er.2017-00103.
10
An Attenuated Salmonella enterica Serovar Typhimurium Strain and Galacto-Oligosaccharides Accelerate Clearance of Salmonella Infections in Poultry through Modifications to the Gut Microbiome.减毒鼠伤寒沙门氏菌菌株和半乳糖寡糖通过改变肠道微生物组加速家禽中沙门氏菌感染的清除。
Appl Environ Microbiol. 2018 Feb 14;84(5). doi: 10.1128/AEM.02526-17. Print 2018 Mar 1.
“肠道健康”:医学的新目标?
BMC Med. 2011 Mar 14;9:24. doi: 10.1186/1741-7015-9-24.
4
Has the microbiota played a critical role in the evolution of the adaptive immune system?微生物群在适应性免疫系统的进化中是否发挥了关键作用?
Science. 2010 Dec 24;330(6012):1768-73. doi: 10.1126/science.1195568.
5
Induction of colonic regulatory T cells by indigenous Clostridium species.肠道共生梭菌诱导结肠调节性 T 细胞。
Science. 2011 Jan 21;331(6015):337-41. doi: 10.1126/science.1198469. Epub 2010 Dec 23.
6
Diet, gut microbiota and immune responses.饮食、肠道微生物群和免疫反应。
Nat Immunol. 2011 Jan;12(1):5-9. doi: 10.1038/ni0111-5.
7
Adaptive immunity in the host-microbiota dialog.宿主-微生物群对话中的适应性免疫。
Mucosal Immunol. 2011 Jan;4(1):15-21. doi: 10.1038/mi.2010.60. Epub 2010 Oct 13.
8
Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium.应激源暴露会破坏肠道内的共生微生物种群,导致鼠柠檬酸杆菌的过度定植。
Infect Immun. 2010 Apr;78(4):1509-19. doi: 10.1128/IAI.00862-09. Epub 2010 Feb 9.
9
Site and strain-specific variation in gut microbiota profiles and metabolism in experimental mice.实验小鼠肠道微生物组和代谢的特定部位和菌株差异。
PLoS One. 2010 Jan 5;5(1):e8584. doi: 10.1371/journal.pone.0008584.
10
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine.特定的微生物群引导小肠黏膜中产生白细胞介素-17的辅助性T细胞的分化。
Cell Host Microbe. 2008 Oct 16;4(4):337-49. doi: 10.1016/j.chom.2008.09.009.