Pala Laura, Monami Matteo, Ciani Silvia, Dicembrini Ilaria, Pasqua Alessandro, Pezzatini Anna, Francesconi Paolo, Cresci Barbara, Mannucci Edoardo, Rotella Carlo Maria
SOD of Endocrinology, AOUC, 50139 Florence, Italy.
J Nutr Metab. 2012;2012:253428. doi: 10.1155/2012/253428. Epub 2011 Aug 22.
Background and Aims. The secretion of several adipocytokines, such as adiponectin, retinol-binding protein 4 (RBP4), adipocyte fatty acid binding protein (aFABP), and visfatin, is altered in subjects with abdominal adiposity; these endocrine alterations could contribute to increased cardiovascular risk. The aim of the study was to assess the relationship among adiponectin, RBP4, aFABP, and visfatin, and incident cardiovascular disease. Methods and Results. A case-control study, nested within a prospective cohort, on 2945 subjects enrolled for a diabetes screening program was performed. We studied 18 patients with incident fatal or nonfatal IHD (Ischemic Heart Disease) or CVD (Cerebrovascular Disease), compared with 18 matched control subjects. Circulating adiponectin levels were significantly lower in cases of IHD with respect to controls. Circulating RBP4 levels were significantly increased in CVD and decreased in IHD with respect to controls. Circulating aFABP4 levels were significantly increased in CVD, while no difference was associated with IHD. Circulating visfatin levels were significantly lower in cases of both CVD and IHD with respect to controls, while no difference was associated with CVD. Conclusions. The present study confirms that low adiponectin is associated with increased incidents of IHD, but not CVD, and suggests, for the first time, a major effect of visfatin, aFABP, and RBP4 in the development of cardiovascular disease.
背景与目的。在腹部肥胖的受试者中，几种脂肪细胞因子的分泌会发生改变，如脂联素、视黄醇结合蛋白4（RBP4）、脂肪细胞脂肪酸结合蛋白（aFABP）和内脂素；这些内分泌改变可能会增加心血管疾病风险。本研究的目的是评估脂联素、RBP4、aFABP和内脂素与心血管疾病发病之间的关系。方法与结果。在一项针对2945名参加糖尿病筛查项目的受试者的前瞻性队列研究中进行了一项病例对照研究。我们研究了18例新发致命性或非致命性缺血性心脏病（IHD）或脑血管疾病（CVD）患者，并与18名匹配的对照受试者进行比较。与对照组相比，IHD患者的循环脂联素水平显著降低。与对照组相比，CVD患者的循环RBP4水平显著升高，而IHD患者的循环RBP4水平降低。CVD患者的循环aFABP4水平显著升高，而与IHD无关。与对照组相比，CVD和IHD患者的循环内脂素水平均显著降低，而与CVD无关。结论。本研究证实低脂联素与IHD发病率增加有关，但与CVD无关，并首次表明内脂素、aFABP和RBP4在心血管疾病发生发展中具有重要作用。
